PLASMACYTOID DENDRITIC CELLS HAVING IMMUNE TOLERANCE, AND METHOD FOR PRODUCING SAME

WIPO Patent Application WO/2018/143652

A1

The present invention relates to a method for producing plasmacytoid dendritic cells having immune tolerance, plasmacytoid dendritic cells having immune tolerance produced by the method, and a cell therapeutic agent comprising the cells. The present invention can induce a high yield of plasmacytoid dendritic cells having immune tolerance from immature dendritic cells through a simple and easy process, thereby enabling a stable supply of the plasmacytoid dendritic cells having immune tolerance in large quantities.

SHIN SUNG JAE (KR)
KIM WOO SIK (KR)
KIM HONG MIN (KR)

PCT/KR2018/001299

August 09, 2018

January 30, 2018

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QURATIS INC (KR)

C12N5/0784; A61K35/15

US20090131512A1	2009-05-21
US9370558B2	2016-06-21

BJORCK, PIA: "Plasmacytoid dendritic cell dichotomy: identification of IFN- a producing cells as a phenotypically and functionally distinct subset", THE JOURNAL OF IMMUNOLOGY, vol. 186, 2011, pages 1477 - 1485, XP055531717
SIOUD ET AL.: "TLR agonists induce the differentiation of human bone marrow CD 34+ progenitors into CDllc+ CD 80/86+ DC capable of inducing a Th1? type response", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 37, no. 10, 2007, pages 2834 - 2846, XP008141629
LIU, KO-JIUNN: "Dendritic cell , toll-like receptor, and the immune system", JOURNAL OF CANCER MOLECULES, 2006, pages 213 - 215, XP008133133
See also references of EP 3578642A4

KIM, Soon Woong (KR)

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