Title:
PLASMONIC NANOCAVITY ARRAY SENSORS FOR ANALYTE DETECTION ENHANCEMENT AND METHODS FOR MAKING AND USING OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2014/197097
Kind Code:
A3
Abstract:
This disclosure provides, among other things, a nanosensor for sensing an analyte. In some embodiments the nanosensor comprises (a) a substrate; (b) a signal amplification layer comprising: (i) a substantially continuous metallic backplane on the substrate; (ii) one or a plurality of pillars extending from the metallic backplane or from the substrate through holes in the backplane; and (iii) a metallic disk on top of the pillar, wherein at least one portion of the edge of the disk is separated from the metallic backplane; and (c) a capture agent that specifically binds to the analyte, wherein the capture agent is linked to the surface of the signal amplification layer; wherein the nanosensor amplifies a light signal from an analyte, when the analyte is bound to the capture agent. Methods for fabricating the nanosensor and methods for using the nanosensor are also provided.
Inventors:
CHOU STEPHEN Y (US)
CHEN HAO (US)
CHEN HAO (US)
Application Number:
PCT/US2014/030108
Publication Date:
January 22, 2015
Filing Date:
March 16, 2014
Export Citation:
Assignee:
UNIV PRINCETON (US)
International Classes:
G01N27/26; G01N21/65; G03F7/00
Domestic Patent References:
| WO2012024006A2 | 2012-02-23 | |||
| WO2009029550A2 | 2009-03-05 |
Foreign References:
| US20090149344A1 | 2009-06-11 | |||
| US20110143375A1 | 2011-06-16 |
Other References:
TAN, H ET AL.: "Roller Nanoimprint Lithography.", J. VAC. SCI. TECHNOL. B., vol. 16, no. 6, November 1998 (1998-11-01), XP012007312
Attorney, Agent or Firm:
KEDDIE, James S. (Field & Francis LLP1900 University Avenue, Suite 20, East Palo Alto California, US)
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