Title:
PLATELET AGGREGATOR
Document Type and Number:
WIPO Patent Application WO/2021/141066
Kind Code:
A1
Abstract:
The present invention pertains to a platelet aggregator that contains amorphous polyphosphoric acid as an active ingredient, wherein the polyphosphoric acid is a Ca salt of polyphosphoric acid. The platelet aggregator acts on damaged gastrointestinal mucosa in inflammatory bowel disease and can bring about remission/improvement of the inflammatory bowel disease by exerting a platelet aggregating effect.
Inventors:
FUJIYA MIKIHIRO (JP)
KONISHI HIROAKI (JP)
TANAKA HIROKI (JP)
ISOZAKI SHOTARO (JP)
OMACHI YOSHIHIRO (JP)
OGAWA NAOKI (JP)
KONISHI HIROAKI (JP)
TANAKA HIROKI (JP)
ISOZAKI SHOTARO (JP)
OMACHI YOSHIHIRO (JP)
OGAWA NAOKI (JP)
Application Number:
PCT/JP2021/000261
Publication Date:
July 15, 2021
Filing Date:
January 07, 2021
Export Citation:
Assignee:
KAMUI PHARMA INC (JP)
NATIONAL UNIV CORPORATION ASAHIKAWA MEDICAL UNIV (JP)
NATIONAL UNIV CORPORATION ASAHIKAWA MEDICAL UNIV (JP)
International Classes:
A61K33/42; A61K9/14; A61P1/04; A61P7/04; A61P17/02
Domestic Patent References:
| WO2014138662A1 | 2014-09-12 | |||
| WO2011125619A1 | 2011-10-13 | |||
| WO2011125619A1 | 2011-10-13 | |||
| WO2016079006A1 | 2016-05-26 |
Foreign References:
| JP2010513291A | 2010-04-30 | |||
| JP2020001319A | 2020-01-09 |
Other References:
DONOVAN, A. J. ET AL.: "Size-Controlled Synthesis of Granular Polyphosphate Nanoparticles at Physiologic Salt Concentrations for Blood Clotting", BIOMACROMOLECULES, vol. 15, 2014, pages 3976 - 3984, XP055422473, DOI: 10.1021/bm501046t
DONOVAN ALEXANDER J., KALKOWSKI JOSEPH, SZYMUSIAK MAGDALENA, WANG CANHUI, SMITH STEPHANIE A., KLIE ROBERT F., MORRISSEY JAMES H., : "Artificial Dense Granules: A Procoagulant Liposomal formulation Modeled after Platelet Polyphosphate Storage Pools", BIOMACROMOLECULES, vol. 17, no. 8, 2016, pages 2572 - 2581, XP055840967
YANG XIAOYANG, WAN MENGJIE, LIANG TING, PENG MINYUAN, CHEN FANGPING: "Synthetic polyphosphate inhibits endogenous coagulation and platelet aggregation in vitro", BIOMED. REP ., vol. 6, 2017, pages 57 - 62, XP055840969
FUJIYA MIKIHIRO, UENO NOBUHIRO, KASHIMA SHIN, TANAKA KAZUYUKI, SAKATANI AKI, ANDO KATSUYOSHI, MORIICHI KENTARO, KONISHI HIROAKI, K: "Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis", CLIN. PHARMACOL . THER., vol. 107, no. 2, February 2020 (2020-02-01), pages 452 - 461, XP055840972
FUJITA ET AL.: "Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis", CLIN PHARMACOL THER, September 2019 (2019-09-01)
FENG ET AL.: "Biogenic Polyphosphate Nanoparticles from a Marine Cyanobacterium Synechococcus sp. PCC 7002: Production, Characterization, and Anti-Inflammatory Properties In Vitro", MAR DRUGS, vol. 16, no. 9, 10 September 2018 (2018-09-10)
FENG ET AL.: "Biogenic Polyphosphate Nanoparticles from Synechococcus sp. PCC 7002 Exhibit Intestinal Protective Potential in Human Intestinal Epithelial Cells In Vitro and Murine Small Intestine Ex Vivo", J AGRIC FOOD CHEM., vol. 66, no. 30, 1 August 2018 (2018-08-01), pages 8026 - 8035
DONOVAN ET AL.: "Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting", BIOMACROMOLECULES, vol. 15, no. 11, 10 November 2014 (2014-11-10), pages 3976 - 84, XP055422473, DOI: 10.1021/bm501046t
BERG DJ ET AL., J CLIN INVEST, 1998
CHAN MV ET AL., PLATELETS, 2018
See also references of EP 4101455A4
DONOVAN ALEXANDER J., KALKOWSKI JOSEPH, SZYMUSIAK MAGDALENA, WANG CANHUI, SMITH STEPHANIE A., KLIE ROBERT F., MORRISSEY JAMES H., : "Artificial Dense Granules: A Procoagulant Liposomal formulation Modeled after Platelet Polyphosphate Storage Pools", BIOMACROMOLECULES, vol. 17, no. 8, 2016, pages 2572 - 2581, XP055840967
YANG XIAOYANG, WAN MENGJIE, LIANG TING, PENG MINYUAN, CHEN FANGPING: "Synthetic polyphosphate inhibits endogenous coagulation and platelet aggregation in vitro", BIOMED. REP ., vol. 6, 2017, pages 57 - 62, XP055840969
FUJIYA MIKIHIRO, UENO NOBUHIRO, KASHIMA SHIN, TANAKA KAZUYUKI, SAKATANI AKI, ANDO KATSUYOSHI, MORIICHI KENTARO, KONISHI HIROAKI, K: "Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis", CLIN. PHARMACOL . THER., vol. 107, no. 2, February 2020 (2020-02-01), pages 452 - 461, XP055840972
FUJITA ET AL.: "Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis", CLIN PHARMACOL THER, September 2019 (2019-09-01)
FENG ET AL.: "Biogenic Polyphosphate Nanoparticles from a Marine Cyanobacterium Synechococcus sp. PCC 7002: Production, Characterization, and Anti-Inflammatory Properties In Vitro", MAR DRUGS, vol. 16, no. 9, 10 September 2018 (2018-09-10)
FENG ET AL.: "Biogenic Polyphosphate Nanoparticles from Synechococcus sp. PCC 7002 Exhibit Intestinal Protective Potential in Human Intestinal Epithelial Cells In Vitro and Murine Small Intestine Ex Vivo", J AGRIC FOOD CHEM., vol. 66, no. 30, 1 August 2018 (2018-08-01), pages 8026 - 8035
DONOVAN ET AL.: "Size-controlled synthesis of granular polyphosphate nanoparticles at physiologic salt concentrations for blood clotting", BIOMACROMOLECULES, vol. 15, no. 11, 10 November 2014 (2014-11-10), pages 3976 - 84, XP055422473, DOI: 10.1021/bm501046t
BERG DJ ET AL., J CLIN INVEST, 1998
CHAN MV ET AL., PLATELETS, 2018
See also references of EP 4101455A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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