Title:
A PLATFORM FOR T LYMPHOCYTE GENOME ENGINEERING AND IN VIVO HIGH-THROUGHPUT SCREENING THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/195073
Kind Code:
A3
Abstract:
The present invention includes compositions and methods for T cell genome editing and screening in vivo. In certain aspects, the invention includes an sgRNA library for genome-scale mutagenesis.
Inventors:
CHEN SIDI (US)
DONG MATTHEW (US)
DONG MATTHEW (US)
Application Number:
PCT/US2018/027967
Publication Date:
December 06, 2018
Filing Date:
April 17, 2018
Export Citation:
Assignee:
UNIV YALE (US)
International Classes:
C12N15/11; C12N15/63
Domestic Patent References:
| WO2017081097A1 | 2017-05-18 |
Foreign References:
| US20160168594A1 | 2016-06-16 | |||
| US20090187997A1 | 2009-07-23 | |||
| US20050214823A1 | 2005-09-29 | |||
| US20160311908A1 | 2016-10-27 |
Attorney, Agent or Firm:
DOYLE, Kathryn et al. (US)
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