Title:
PLATINUM-BASED DRUG CARBON NANODOT, AND METHOD FOR PREPARING SAME AND CARBON NANODOT PROTEIN COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/040728
Kind Code:
A1
Abstract:
Provided are a platinum-based drug carbon nanodot and a method for preparing same and a carbon nanodot protein compound and use thereof. The platinum-based drug carbon nanodot comprises a carbon-based core having the characteristic of visible light absorption. The carbon-based core is combined with a tetravalent platinum element via a coordinate bond, and the platinum-based drug carbon nanodot can be reduced under light irradiation conditions to obtain a divalent platinum compound and a hydroxyl radical. The method for preparing the platinum-based drug carbon nanodot comprises subjecting a disubstituted aromatic compound and a tetravalent platinum compound to a solvothermal reaction to obtain the platinum-based drug carbon nanodot. Under irradiation of visible light, the carbon-based core generates hole-electron pairs. Excited-state electrons are captured by platinum (IV) to undergo a reduction reaction, which rapidly generates a Pt (II) compound with high cytotoxicity and a hydroxyl radical and reduces the pH value of cells and a tumor site, resulting in immunogenic death of cancer cells and activation of the anti-tumor immune response of the body as well while killing the cancer cells. The platinum-based drug carbon nanodot and the protein compound thereof of the present invention can serve as a high-efficiency photoactive anti-cancer drug for precision treatment of tumors.
Inventors:
QU SONGNAN (CN)
GUO DONGBO (CN)
TANG ZIKANG (CN)
GUO DONGBO (CN)
TANG ZIKANG (CN)
Application Number:
PCT/CN2022/126494
Publication Date:
February 29, 2024
Filing Date:
October 20, 2022
Export Citation:
Assignee:
UNIV MACAU (CN)
International Classes:
A61K41/00; A61K33/243; A61K47/42; A61P35/00; A61P35/04
Foreign References:
| TW202146001A | 2021-12-16 | |||
| CN112402619A | 2021-02-26 |
Other References:
BAO, YANWEN ET AL.: "Platinum-doped Carbon Nanoparticles Inhibit Cancer Cell Migration under Mild Laser Irradiation: Multi-organelle-targeted Photothermal Therapy", BIOMATERIALS, vol. 183, 14 August 2018 (2018-08-14)
任国栋 (REN, GUODONG): "构建靶向EGFR 的纳米载药体系及对食管癌的协同治疗 (Construction of EGFR-targeted Nano Drug Delivery System and Synergistic Treatment for Esophageal Cancer)", 中国优秀硕士学位论文全文库 (CHINA MASTER’S THESES FULL-TEXT DATABASE), no. 1, 15 January 2022 (2022-01-15)
FENGSHOU WU;LIANGLIANG YUE;HUIFANG SU;KAI WANG;LIXIA YANG;XUNJIN ZHU: "Carbon Dots @ Platinum Porphyrin Composite as Theranostic Nanoagent for Efficient Photodynamic Cancer Therapy", NANOSCALE RESEARCH LETTERS, SPRINGER, US, vol. 13, no. 1, 8 November 2018 (2018-11-08), US , pages 1 - 10, XP021262385, ISSN: 1931-7573, DOI: 10.1186/s11671-018-2761-5
MURALI G., KWON BINHEE, KANG HANSOL, MODIGUNTA JEEVAN KUMAR REDDY, PARK SEONGMIN, LEE SEONGEUN, LEE HWIYOUNG, PARK YOUNG HO, KIM J: "Hematoporphyrin Photosensitizer-Linked Carbon Quantum Dots for Photodynamic Therapy of Cancer Cells", ACS APPLIED NANO MATERIALS, vol. 5, no. 3, 25 March 2022 (2022-03-25), pages 4376 - 4385, XP093144608, ISSN: 2574-0970, DOI: 10.1021/acsanm.2c00443
DESMOND LIAM JOSEPH, PHAN ANH N., GENTILE PIERGIORGIO: "Critical overview on the green synthesis of carbon quantum dots and their application for cancer therapy", ENVIRONMENTAL SCIENCE: NANO, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 8, no. 4, 22 April 2021 (2021-04-22), GB , pages 848 - 862, XP093144611, ISSN: 2051-8153, DOI: 10.1039/D1EN00017A
任国栋 (REN, GUODONG): "构建靶向EGFR 的纳米载药体系及对食管癌的协同治疗 (Construction of EGFR-targeted Nano Drug Delivery System and Synergistic Treatment for Esophageal Cancer)", 中国优秀硕士学位论文全文库 (CHINA MASTER’S THESES FULL-TEXT DATABASE), no. 1, 15 January 2022 (2022-01-15)
FENGSHOU WU;LIANGLIANG YUE;HUIFANG SU;KAI WANG;LIXIA YANG;XUNJIN ZHU: "Carbon Dots @ Platinum Porphyrin Composite as Theranostic Nanoagent for Efficient Photodynamic Cancer Therapy", NANOSCALE RESEARCH LETTERS, SPRINGER, US, vol. 13, no. 1, 8 November 2018 (2018-11-08), US , pages 1 - 10, XP021262385, ISSN: 1931-7573, DOI: 10.1186/s11671-018-2761-5
MURALI G., KWON BINHEE, KANG HANSOL, MODIGUNTA JEEVAN KUMAR REDDY, PARK SEONGMIN, LEE SEONGEUN, LEE HWIYOUNG, PARK YOUNG HO, KIM J: "Hematoporphyrin Photosensitizer-Linked Carbon Quantum Dots for Photodynamic Therapy of Cancer Cells", ACS APPLIED NANO MATERIALS, vol. 5, no. 3, 25 March 2022 (2022-03-25), pages 4376 - 4385, XP093144608, ISSN: 2574-0970, DOI: 10.1021/acsanm.2c00443
DESMOND LIAM JOSEPH, PHAN ANH N., GENTILE PIERGIORGIO: "Critical overview on the green synthesis of carbon quantum dots and their application for cancer therapy", ENVIRONMENTAL SCIENCE: NANO, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 8, no. 4, 22 April 2021 (2021-04-22), GB , pages 848 - 862, XP093144611, ISSN: 2051-8153, DOI: 10.1039/D1EN00017A
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
Download PDF: