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Title:
PLATINUM COMPLEX AND MEDICAL COMPOUND CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2010/026711
Kind Code:
A1
Abstract:
Disclosed is a new platinum complex, and medical compound containing same, which has strong antineoplastic activity and is efficacious at smaller doses. The platinum complex has a spiro [4,4]nonane-1,6-diamine represented by general formula (A) as the platinum complex’s ligand. (In the formula, X and Y are the same or different, and each represents a halogen atom, or X and Y jointly represent a bivalent residue represented by formula (Z).) Said platinum complex has strong antineoplastic activity and is efficacious as a therapeutic agent for malignant tumors.

Inventors:
ARAI HISAE (JP)
OHNO MASAJI (JP)
KONDO HISAO (JP)
ARAI IKUKO (JP)
Application Number:
PCT/JP2009/004077
Publication Date:
March 11, 2010
Filing Date:
August 25, 2009
Export Citation:
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Assignee:
UNITECH CO LTD (JP)
ARAI HISAE (JP)
OHNO MASAJI (JP)
KONDO HISAO (JP)
ARAI IKUKO (JP)
International Classes:
C07C211/38; A61K31/555; A61P35/00; C07C55/06; C07C61/04; C07F15/00
Domestic Patent References:
WO2005007662A22005-01-27
Foreign References:
JPH02108693A1990-04-20
US4140707A1979-02-20
Other References:
VARELA, J.A. ET AL.: "One-Step Synthesis of Spiropyridines, a Novel Class of C2-Symmetric Chiral Ligands, by Cobalt(I)-Catalyzed [2+2+2] Cycloadditions between Bis-Alkynenitriles and Alkynes", ORGANIC LETTERS, vol. 1, no. 13, 1999, pages 2141 - 2143, XP008143129
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J.A. NIEMAN; B.A. KEAY, SYNTHETIC COMN., vol. 29, 1999, pages 3929
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A.C.C. CHAN ET AL., TETRAHEDRON. LETT., vol. 45, 2004, pages 7379
E. J. COREY; R. K. BAKSHI; S. SHIBATA, J. AM. CHEM. SOC., vol. 109, 1987, pages 5551
See also references of EP 2325163A4
Attorney, Agent or Firm:
MORIYA, KAZUO (JP)
Kazuo Moriya (JP)
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