Title:
PLATINUM COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2014/043243
Kind Code:
A3
Abstract:
The present disclosure relates to novel pharmaceutical compositions comprising a nanoparticle associated with, tether to, or encapsulating a platinum-based active pharmaceutical agent. The platinum-based drug is released from the nanoparticles in a controlled fashion. Also contemplated are methods of making the nanoparticles, as well as methods for using them in the treatment or prevention of diseases or conditions. One embodiment relates to phenanthriplatin nanoparticles and methods of using and making the same.
Inventors:
BILODEAU MARK T (US)
DUNBAR CRAIG A (US)
BARDER TIMOTHY E (US)
LEE EDWARD R (US)
ALARGOVA ROSSITZA G (US)
ROCKWOOD DANIELLE N (US)
MOREAU BENOIT (US)
SHINDE RAJESH (US)
BOUTHILLETTE MELANEY (US)
DUNBAR CRAIG A (US)
BARDER TIMOTHY E (US)
LEE EDWARD R (US)
ALARGOVA ROSSITZA G (US)
ROCKWOOD DANIELLE N (US)
MOREAU BENOIT (US)
SHINDE RAJESH (US)
BOUTHILLETTE MELANEY (US)
Application Number:
PCT/US2013/059276
Publication Date:
July 16, 2015
Filing Date:
September 11, 2013
Export Citation:
Assignee:
BLEND THERAPEUTICS (US)
International Classes:
A01N55/02; C07F15/00
Other References:
PARK ET AL.: "Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile", PNAS, vol. 109, no. 30, 24 July 2012 (2012-07-24), pages 11987 - 11992
ABU-SURRAH ET AL.: "Platinum Group Antitumor Chemistry: Design and development of New Anticancer Drugs Complementary to Cisplatin", CURRENT MEDICINAL CHEMISTRY, vol. 13, no. 11, 2006, pages 1337 - 1357
ABU-SURRAH ET AL.: "Platinum Group Antitumor Chemistry: Design and development of New Anticancer Drugs Complementary to Cisplatin", CURRENT MEDICINAL CHEMISTRY, vol. 13, no. 11, 2006, pages 1337 - 1357
Attorney, Agent or Firm:
MAHONEY, Joseph, A. (P.O. Box 2828Chicago, IL, US)
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