Title:
PLATINUM(IV) COMPOUNDS AND METHODS OF MAKING AND USING SAME
Document Type and Number:
WIPO Patent Application WO/2015/134599
Kind Code:
A3
Abstract:
Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, the conditions effective for the cycloaddition reaction to form the heterocyclic compound includes the substantial absence of added catalyst (e.g., copper catalyst).
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Inventors:
DHAR SHANTA (US)
PATHAK RAKESH K (US)
POPIK VLADIMIR V (US)
MCNITT CHRISTOPHER D (US)
PATHAK RAKESH K (US)
POPIK VLADIMIR V (US)
MCNITT CHRISTOPHER D (US)
Application Number:
PCT/US2015/018720
Publication Date:
October 29, 2015
Filing Date:
March 04, 2015
Export Citation:
Assignee:
UNIV GEORGIA (US)
DHAR SHANTA (US)
PATHAK RAKESH K (US)
POPIK VLADIMIR V (US)
MCNITT CHRISTOPHER D (US)
DHAR SHANTA (US)
PATHAK RAKESH K (US)
POPIK VLADIMIR V (US)
MCNITT CHRISTOPHER D (US)
International Classes:
A61K31/282; C07D225/08; C07D249/16
Foreign References:
US20110256227A1 | 2011-10-20 | |||
US20100210854A1 | 2010-08-19 | |||
US20130310570A1 | 2013-11-21 | |||
US20110257261A1 | 2011-10-20 |
Other References:
SANDERS ET AL.: "Metal-Free Sequential [3 + 2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity", J. AM. CHEM. SOC., vol. 133, 2011, pages 949 - 957, XP055114630
WHITE ET AL.: "Picazoplatin, an Azide-Containing Platinum(ll) Derivative for Target Analysis by Click Chemistry", J. AM. CHEM. SOC., vol. 135, 2013, pages 11680 - 11683, XP055233672
HIROYA ET AL.: "Cyclization Reactions of Homopropargyl Azide Derivatives Catalyzed by PtCl4 in Ethanol Solution: Synthesis of Functionalized Pyrrole Derivatives", ORGANIC LETTERS, vol. 8, 2006, pages 5349 - 5352
BANERT ET AL.: "Synthesis with Perfect Atom Economy: Generation of Diazo Ketones by 1,3- Dipolar Cycloaddition of Nitrous Oxide at Cyclic Alkynes under Mild Conditions.", ANGEW. CHEM., vol. 50, 2011, pages 6171 - 6174
BUTLER ET AL.: "Targeted delivery of platinum-based anticancer complexes", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 17, 2013, pages 175 - 188
WHITE ET AL.: "Picazoplatin, an Azide-Containing Platinum(ll) Derivative for Target Analysis by Click Chemistry", J. AM. CHEM. SOC., vol. 135, 2013, pages 11680 - 11683, XP055233672
HIROYA ET AL.: "Cyclization Reactions of Homopropargyl Azide Derivatives Catalyzed by PtCl4 in Ethanol Solution: Synthesis of Functionalized Pyrrole Derivatives", ORGANIC LETTERS, vol. 8, 2006, pages 5349 - 5352
BANERT ET AL.: "Synthesis with Perfect Atom Economy: Generation of Diazo Ketones by 1,3- Dipolar Cycloaddition of Nitrous Oxide at Cyclic Alkynes under Mild Conditions.", ANGEW. CHEM., vol. 50, 2011, pages 6171 - 6174
BUTLER ET AL.: "Targeted delivery of platinum-based anticancer complexes", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 17, 2013, pages 175 - 188
Attorney, Agent or Firm:
ALBIN, Loren, D. (Raasch & Gebhardt P.A.,P.O. Box 58133, Minneapolis MN, US)
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