Title:
PLGA MICROPARTICLES, SUSTAINED RELEASE FORMULATION THEREOF AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2020/183718
Kind Code:
A1
Abstract:
The present invention provides: roughly spherical poly(lactic-co-glycolic acid) (PLGA) microparticles which have a volume-based average particle diameter of 1-150 μm inclusive, the relative span factor (R.S.F.) of which satisfies requirement (1): 0.1<(R.S.F.)≤1.7 [wherein: R.S.F. means (D90-D10)/D50; D90 represents a particle diameter corresponding to 90 vol% accumulated from the smaller particle side in the cumulative particle size distribution; D50 represents a particle diameter corresponding to 50 vol% accumulated from the smaller particle side in the cumulative particle size distribution; and D10 represents a particle diameter corresponding to 10 vol% accumulated from the smaller particle side in the cumulative particle size distribution] and which contain a physiologically active substance; and a method for efficiently manufacturing the same. According to the present invention, provided are roughly spherical PLGA microparticles which include few coarse or fine particles, show a sharp particle diameter distribution centering on a desired particle diameter, and have a volume-based average particle diameter of 1-150 μm inclusive, without performing a classification step.
Inventors:
ENOMURA MASAKAZU (JP)
ARAKI KAEKO (JP)
ARAKI KAEKO (JP)
Application Number:
PCT/JP2019/010618
Publication Date:
September 17, 2020
Filing Date:
March 14, 2019
Export Citation:
Assignee:
M TECHNIQUE CO LTD (JP)
International Classes:
A61K9/52; A61J3/06; A61K47/34
Domestic Patent References:
| WO2016039359A1 | 2016-03-17 | |||
| WO2017147285A1 | 2017-08-31 |
Foreign References:
| JP2001512461A | 2001-08-21 | |||
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Other References:
See also references of EP 3939575A4
Attorney, Agent or Firm:
SAKAMOTO Tomohiro (JP)
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