Title:
PLURIPOTENT CELLS COMPRISING ALLOGENIC NUCLEUS AND MITOCHONDRIA
Document Type and Number:
WIPO Patent Application WO2001079445
Kind Code:
A3
Abstract:
Allochimeric ES cells are provided having nuclei from one individual of a species and mitochondria from a different individual of the same species. The ES cells can be used for differentiation into differentiated cell types for therapy or for studying various developmental processes in forming embryos and differentiation.
Inventors:
WEST MICHAEL D (US)
Application Number:
PCT/US2001/012265
Publication Date:
July 11, 2002
Filing Date:
April 16, 2001
Export Citation:
Assignee:
ADVANCED CELL TECH INC (US)
WEST MICHAEL D (US)
WEST MICHAEL D (US)
International Classes:
A01K67/027; A61K38/00; A61K48/00; A61P37/02; C12N15/09; A61P43/00; C12N5/0735; C12N5/10; C12N5/16; C12N5/26; C12N15/873; A61K35/12; (IPC1-7): A61K63/00; C12N5/00; C12N5/02; C12N5/08; C12N15/00
Foreign References:
| US6011197A | 2000-01-04 |
Other References:
WOLF D.P. ET AL.: "Nuclear transfer in the rhesus monkey: Practical and basic implications", BIOLOGY OF REPRODUCTION, vol. 60, 1999, pages 199 - 204, XP002946450
EVANS M.J. ET AL.: "Mitochondrial DNA genotypes in nuclear transfer-derived sheep", NATURE GENETICS, vol. 23, September 1999 (1999-09-01), pages 90 - 93, XP002946451
TAKEDA K. ET AL.: "Dominant distribution of mitochondrial DNA from recipient oocytes in bovine embryos and offspring after nuclear transfer", JOURNAL OF REPRODUCTION AND FERTILITY, vol. 116, 1999, pages 253 - 259, XP002946449
EVANS M.J. ET AL.: "Mitochondrial DNA genotypes in nuclear transfer-derived sheep", NATURE GENETICS, vol. 23, September 1999 (1999-09-01), pages 90 - 93, XP002946451
TAKEDA K. ET AL.: "Dominant distribution of mitochondrial DNA from recipient oocytes in bovine embryos and offspring after nuclear transfer", JOURNAL OF REPRODUCTION AND FERTILITY, vol. 116, 1999, pages 253 - 259, XP002946449
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