Title:
PLURIPOTENT STEM CELL CAPABLE OF BEING ISOLATED FROM FAT TISSUE OR UMBILICAL CORD OF BIOLOGICAL BODY
Document Type and Number:
WIPO Patent Application WO/2012/133942
Kind Code:
A1
Abstract:
The present invention provides a method for directly obtaining a pluripotent stem cell from the fat tissue or the umbilical cord of a biological body, and the pluripotent stem cell obtained by means of the aforementioned method. A SSEA-3 positive and CD105 positive pluripotent stem cell which is capable of being isolated from the fat tissue or the umbilical cord of a biological body by using the expression of SSEA-3 as an index and which has all of the following properties: (i) has little or no telomerase activity; (ii) is capable of differentiating into any of the triploblastic cells; (iii) does not exhibit neoplastic propagation; and (iv) exerts replication competence (self-renewal abilities).
Inventors:
DEZAWA MARI (JP)
YOSHIDA MASANORI (JP)
YOSHIDA MASANORI (JP)
Application Number:
PCT/JP2012/059422
Publication Date:
October 04, 2012
Filing Date:
March 30, 2012
Export Citation:
Assignee:
CLIO INC (JP)
DEZAWA MARI (JP)
YOSHIDA MASANORI (JP)
DEZAWA MARI (JP)
YOSHIDA MASANORI (JP)
International Classes:
C12N5/071; A61K35/28; A61K35/44; A61L27/00; A61P9/10; A61P21/02; A61P25/16
Domestic Patent References:
| WO2011007900A1 | 2011-01-20 |
Other References:
MARI DEZAWA: "Hifu / Kotsuzui Yurai Kansaibo ''Muse''", RINSHO HYOKA (CLINICAL EVALUATION), vol. 38, no. 4, 1 March 2011 (2011-03-01), pages 749 - 760
KURODA Y ET AL.: "Unique multipotent cells in adult human mesenchymal cell populations.", PROC NATL ACAD SCI U S A., vol. 107, no. 19, 11 May 2010 (2010-05-11), pages 8639 - 8643, XP008152782, DOI: doi:10.1073/pnas.0911647107
MARI DEZAWA: "Hito Seitai Yurai no Tanosei Kansaibo no Hakken to Shinkei Saisei Iryo eno Oyo no Kanosei", REGENERATIVE MEDICINE, vol. 10, 1 February 2011 (2011-02-01), pages 107
JO C H ET AL.: "Fetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansion.", CELL TISSUE RES., vol. 334, no. 3, 22 October 2008 (2008-10-22), pages 423 - 433, XP019716547
KURODA Y ET AL.: "Unique multipotent cells in adult human mesenchymal cell populations.", PROC NATL ACAD SCI U S A., vol. 107, no. 19, 11 May 2010 (2010-05-11), pages 8639 - 8643, XP008152782, DOI: doi:10.1073/pnas.0911647107
MARI DEZAWA: "Hito Seitai Yurai no Tanosei Kansaibo no Hakken to Shinkei Saisei Iryo eno Oyo no Kanosei", REGENERATIVE MEDICINE, vol. 10, 1 February 2011 (2011-02-01), pages 107
JO C H ET AL.: "Fetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansion.", CELL TISSUE RES., vol. 334, no. 3, 22 October 2008 (2008-10-22), pages 423 - 433, XP019716547
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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