Title:
PLURIPOTENT STEM CELL THAT INDUCES REPAIR AND REGENERATION AFTER MYOCARDIAL INFARCTION
Document Type and Number:
WIPO Patent Application WO/2014/027474
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a new medical application using pluripotent stem cells (Muse cells) for regenerative medicine. The present invention provides a cell formulation for treating myocardial infarctions, especially severe, large-scale myocardial infarctions, and accompanying heart failure. Said cell formulation contains SSEA3-positive pluripotent stem cells isolated from either mesenchymal tissue from an organism or cultured mesenchymal cells. This cell formulation is based on the following myocardial-tissue regeneration mechanism: intravenous administration of Muse cells to subjects with the abovementioned disorders results in said Muse cells selectively accumulating in the damaged myocardial tissue and, within said tissue, differentiating into cardiac muscle.
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Inventors:
YOSHIDA MASANORI (JP)
MINATOGUCHI SHINYA (JP)
DEZAWA MARI (JP)
MINATOGUCHI SHINYA (JP)
DEZAWA MARI (JP)
Application Number:
PCT/JP2013/054049
Publication Date:
February 20, 2014
Filing Date:
February 19, 2013
Export Citation:
Assignee:
CLIO INC (JP)
UNIV GIFU (JP)
UNIV TOHOKU (JP)
UNIV GIFU (JP)
UNIV TOHOKU (JP)
International Classes:
A61K35/12; A61K35/28; A61P9/10; C12N5/0789
Domestic Patent References:
| WO2011007900A1 | 2011-01-20 | |||
| WO2012054501A1 | 2012-04-26 |
Foreign References:
| JP2002511094A | 2002-04-09 | |||
| JP2002521493A | 2002-07-16 |
Other References:
YASUMASA KURODA ET AL: "UNIQUE MULTIPOTENT CELLS IN ADULT HUMAN MESENCHYMAL CELL POPULATIONS", PROC. NATL.ACAD.SCIE USA, vol. 107, no. 19, 2010, pages 8639 - 8643
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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