Title:
POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2010/111626
Kind Code:
A3
Abstract:
Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
Inventors:
BROWN JASON W (US)
GANGLOFF ANTHONY R (US)
JENNINGS ANDREW JOHN (US)
VU PHONG H (US)
GANGLOFF ANTHONY R (US)
JENNINGS ANDREW JOHN (US)
VU PHONG H (US)
Application Number:
PCT/US2010/028878
Publication Date:
November 18, 2010
Filing Date:
March 26, 2010
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
BROWN JASON W (US)
GANGLOFF ANTHONY R (US)
JENNINGS ANDREW JOHN (US)
VU PHONG H (US)
BROWN JASON W (US)
GANGLOFF ANTHONY R (US)
JENNINGS ANDREW JOHN (US)
VU PHONG H (US)
International Classes:
A61K31/538; C07D265/36; A61P3/00; A61P9/00; A61P25/28; A61P29/00; A61P35/00; C07D413/06; C07D413/12; C07D413/14; C07D417/12; C07D473/12
Domestic Patent References:
| WO2006024517A1 | 2006-03-09 |
Foreign References:
| US20050075347A1 | 2005-04-07 | |||
| JP2007137818A | 2007-06-07 | |||
| US20070179165A1 | 2007-08-02 | |||
| US20040029734A1 | 2004-02-12 | |||
| US4929269A | 1990-05-29 | |||
| US6191127B1 | 2001-02-20 |
Other References:
SMID PIETER ET AL: "Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyllpiperazines, novel potential Antipsychotics combining potent dopamine D-2 receptor antagonism with potent serotonin reuptake inhibition", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM050148Z, vol. 48, no. 22, 1 November 2005 (2005-11-01), pages 6855 - 6869, XP002458793, ISSN: 0022-2623
DAI W M ET AL: "Microwave-assisted one-pot regioselective synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL LNKD- DOI:10.1016/J.TET.2005.04.072, vol. 61, no. 28, 11 July 2005 (2005-07-11), pages 6879 - 6885, XP025383447, ISSN: 0040-4020, [retrieved on 20050711]
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1963, BASSIGNANA, P. ET AL: "Infrared spectra of some compounds with thiazole and oxazole rings. The C:N bond", XP002591503, retrieved from STN Database accession no. 1963:472873
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1938, COLES, HAROLD W. ET AL: "Preparation of 2-methyl-8-carboxy-3-keto-3,4-dihydro-1,4-benzoxazine", XP002591504, retrieved from STN Database accession no. 1938:44905
SHAABAN M R ET AL: "Highly regioselective anodic monofluorination of 2H-1,4-benzoxazin-3(4H)-one derivatives", SYNLETT 2001 DE, no. 10, 2001, pages 1644 - 1646, XP002591505, ISSN: 0936-5214
DAI W M ET AL: "Microwave-assisted one-pot regioselective synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL LNKD- DOI:10.1016/J.TET.2005.04.072, vol. 61, no. 28, 11 July 2005 (2005-07-11), pages 6879 - 6885, XP025383447, ISSN: 0040-4020, [retrieved on 20050711]
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1963, BASSIGNANA, P. ET AL: "Infrared spectra of some compounds with thiazole and oxazole rings. The C:N bond", XP002591503, retrieved from STN Database accession no. 1963:472873
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1938, COLES, HAROLD W. ET AL: "Preparation of 2-methyl-8-carboxy-3-keto-3,4-dihydro-1,4-benzoxazine", XP002591504, retrieved from STN Database accession no. 1938:44905
SHAABAN M R ET AL: "Highly regioselective anodic monofluorination of 2H-1,4-benzoxazin-3(4H)-one derivatives", SYNLETT 2001 DE, no. 10, 2001, pages 1644 - 1646, XP002591505, ISSN: 0936-5214
Attorney, Agent or Firm:
RUSSO, Matthew, J. et al. (Inc.10410 Science Center Driv, San Diego California, US)
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