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Patent Searching and Data


Title:
POLY-CONJUGATE AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/028589
Kind Code:
A1
Abstract:
Provided are a poly-conjugate and a preparation method therefor, and a pharmaceutical composition comprising the poly-conjugate and the use thereof. The poly-conjugate comprises: an amino acid polymer as a main chain and an active pharmaceutical molecule as a branched chain, wherein the active pharmaceutical molecule is 7-ethyl-10-hydroxycamptothecine and linked to the amino acid polymer through one amino acid at 20-hydroxyl. The method for preparing the poly-conjugate comprises the following steps of: 1) adding the amino acid polymer, a compound represented by formula A, a catalyst and a condensing agent into a solvent; 2) bringing the solution obtained in step 1) into contact with a poor solvent, and then filtering same; 3) adding the filter cake obtained in step 2) into the solvent, and bringing same into contact with a deprotection agent to obtain a poly-conjugate. The pharmaceutical composition comprises the poly-conjugate, and a pharmaceutically acceptable adjuvant. The poly-conjugate and pharmaceutical composition are useful in the treatment of a tumour or cancer.

Inventors:
WEN GUANGHUI (CN)
WAN LIUYI (CN)
WANG HAOJUN (CN)
Application Number:
PCT/CN2017/096548
Publication Date:
February 15, 2018
Filing Date:
August 09, 2017
Export Citation:
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Assignee:
BEIJING LABWORLD BIO MEDICINE TECH CORPORATION LTD (CN)
International Classes:
C08G69/48; A61K31/4745; A61K47/00; A61P35/00; C08G81/00
Foreign References:
CN106267227A2017-01-04
CN1429121A2003-07-09
CN101507820A2009-08-19
Other References:
SINGER, JACK W. ET AL.: "Conjugation of Camptothecins to Poly- (L-Glutamic Acid", ANNALS NEW YORK ACADEMY OF SCIENCES, vol. 922, 31 December 2000 (2000-12-31), pages 136 - 150, XP001023451
Attorney, Agent or Firm:
ZHONG LUN LAW FIRM (CN)
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