Title:
POLYAMINE ACTIVATORS ( S PERMINE, S PERMIDINE) OF THE AUTOPHAGIC PATHWAY
Document Type and Number:
WIPO Patent Application WO/2010/081204
Kind Code:
A3
Abstract:
A polyamine compound of the group consisting of putrescine, spermine, spermidine, cholesteryl spermine, spermidine trihydrochloride, spermidine phosphate hexahydrate, spermidine phosphate hexahydrate and 1, 4 -butanediamine N- (3 -aminopropyl) -monohydrochloride or derivatives thereof or combinations thereof which are effective to activate the cellularautophagic pathway for use in a treatment to increase the survivability, lifespan or the life expectancy of an invertebrate animal/poikilotherm invertebrate animal, or to increase the average lifespan of a population of such invertebrate animals.
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Inventors:
WINDERICKX JORIS (BE)
EISENBERG TOBIAS (AT)
KROEMER GUIDO (FR)
MADEO FRANK (AT)
MINOIS NADEGE (GB)
ROCKENFELLER PATRICK (AT)
EISENBERG TOBIAS (AT)
KROEMER GUIDO (FR)
MADEO FRANK (AT)
MINOIS NADEGE (GB)
ROCKENFELLER PATRICK (AT)
Application Number:
PCT/BE2010/000002
Publication Date:
April 14, 2011
Filing Date:
January 14, 2010
Export Citation:
Assignee:
UNIV LEUVEN KATH (BE)
WINDERICKX JORIS (BE)
EISENBERG TOBIAS (AT)
KROEMER GUIDO (FR)
MADEO FRANK (AT)
MINOIS NADEGE (GB)
ROCKENFELLER PATRICK (AT)
WINDERICKX JORIS (BE)
EISENBERG TOBIAS (AT)
KROEMER GUIDO (FR)
MADEO FRANK (AT)
MINOIS NADEGE (GB)
ROCKENFELLER PATRICK (AT)
International Classes:
A61K31/132; A61P43/00
Domestic Patent References:
| WO2009093454A1 | 2009-07-30 |
Other References:
MITSUHASHI JUN: "Polyamine as a growth promoter for cultured insect cells", IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY ANIMAL, vol. 34, no. 8, September 1998 (1998-09-01), pages 619 - 621, XP002608168, ISSN: 1071-2690
QISHENG S ET AL: "Spermine and polylysine enhanced phosphorylation of calmodulin and tubulin in an insect endocrine gland", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 99, no. 1, 1 February 1994 (1994-02-01), ELSEVIER IRELAND LTD, IE, pages 1 - 10, XP025829935, ISSN: 0303-7207, [retrieved on 19940201], DOI: 10.1016/0303-7207(94)90139-2
CAYRE MYRIAM ET AL: "Specific requirement of putrescine for the mitogenic action of juvenile hormone on adult insect neuroblasts", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 15, 1997, pages 8238 - 8242, XP002608169, ISSN: 0027-8424
COCHON ET AL: "Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates", ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, vol. 68, no. 2, 20 September 2007 (2007-09-20), ACADEMIC PRESS, SAN DIEGO, CA, US, pages 286 - 292, XP022262105, ISSN: 0147-6513, DOI: 10.1016/J.ECOENV.2006.11.010
COMBEST W L ET AL: "Polyamines modulate multiple protein phosphorylation pathways in the insect prothoracic gland", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 83, no. 1, 1 January 1992 (1992-01-01), ELSEVIER IRELAND LTD, IE, pages 11 - 19, XP025777701, ISSN: 0303-7207, [retrieved on 19920101], DOI: 10.1016/0303-7207(92)90190-H
GASPARINI STEPHANE ET AL: "The free guanidine and polyamine pools of bivalve mollusks in relation to their ecology", BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol. 28, no. 3, March 2000 (2000-03-01), pages 209 - 218, XP002608170, ISSN: 0305-1978
SCHIPPER RAYMOND G ET AL: "Involvement of polyamines in apoptosis. Facts and controversies: Effectors or protectors?", SEMINARS IN CANCER BIOLOGY, vol. 10, no. 1, February 2000 (2000-02-01), pages 55 - 68, XP002608171, ISSN: 1044-579X
HERNANDEZ S.: "Polyamines as a defense mechanism against lipoperoxidation in Trypanosoma cruzi", ACTA TROPICA, vol. 98, 1 January 2006 (2006-01-01), pages 94 - 102, XP002607628, DOI: 10.1016/j.actatropica.2006.02.005
QISHENG S ET AL: "Spermine and polylysine enhanced phosphorylation of calmodulin and tubulin in an insect endocrine gland", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 99, no. 1, 1 February 1994 (1994-02-01), ELSEVIER IRELAND LTD, IE, pages 1 - 10, XP025829935, ISSN: 0303-7207, [retrieved on 19940201], DOI: 10.1016/0303-7207(94)90139-2
CAYRE MYRIAM ET AL: "Specific requirement of putrescine for the mitogenic action of juvenile hormone on adult insect neuroblasts", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 15, 1997, pages 8238 - 8242, XP002608169, ISSN: 0027-8424
COCHON ET AL: "Differential effects of paraquat on oxidative stress parameters and polyamine levels in two freshwater invertebrates", ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, vol. 68, no. 2, 20 September 2007 (2007-09-20), ACADEMIC PRESS, SAN DIEGO, CA, US, pages 286 - 292, XP022262105, ISSN: 0147-6513, DOI: 10.1016/J.ECOENV.2006.11.010
COMBEST W L ET AL: "Polyamines modulate multiple protein phosphorylation pathways in the insect prothoracic gland", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 83, no. 1, 1 January 1992 (1992-01-01), ELSEVIER IRELAND LTD, IE, pages 11 - 19, XP025777701, ISSN: 0303-7207, [retrieved on 19920101], DOI: 10.1016/0303-7207(92)90190-H
GASPARINI STEPHANE ET AL: "The free guanidine and polyamine pools of bivalve mollusks in relation to their ecology", BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol. 28, no. 3, March 2000 (2000-03-01), pages 209 - 218, XP002608170, ISSN: 0305-1978
SCHIPPER RAYMOND G ET AL: "Involvement of polyamines in apoptosis. Facts and controversies: Effectors or protectors?", SEMINARS IN CANCER BIOLOGY, vol. 10, no. 1, February 2000 (2000-02-01), pages 55 - 68, XP002608171, ISSN: 1044-579X
HERNANDEZ S.: "Polyamines as a defense mechanism against lipoperoxidation in Trypanosoma cruzi", ACTA TROPICA, vol. 98, 1 January 2006 (2006-01-01), pages 94 - 102, XP002607628, DOI: 10.1016/j.actatropica.2006.02.005
Attorney, Agent or Firm:
KATHOLIEKE UNIVERSITEIT LEUVEN (Minderbroedersstraat 8a - bus 5105, Leuven, BE)
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