POLYAMINO ACID DERIVATIVE IN WHICH NUCLEIC ACID ANTIMETABOLITES ARE BONDED

Title:

POLYAMINO ACID DERIVATIVE IN WHICH NUCLEIC ACID ANTIMETABOLITES ARE BONDED

Document Type and Number:

WIPO Patent Application WO/2016/021407

Kind Code:

A1

Abstract:

　The present invention addresses the problem of providing a polymerized prodrug of nucleic acid antimetabolites that improve an antitumor effect and have minimal side effects, particularly myelosuppression. Provided is a polyamino acid derivative in which polyethylene glycol segments and nucleic acid antimetabolites are bonded either directly or via linking bonds to side chain carboxyl groups, wherein the molecular mass of the polyamino acid derivative is 20 kilodaltons to 200 kilodaltons, and the mass content of the polyethylene glycol segments in the polyamino acid derivative is 30 mass% to 90%.

Inventors:

KITAGAWA MASAYUKI (JP)
KAWAMURA DAI (JP)
MIZUNUMA KANA (JP)
NAKAMURA IWAO (JP)
NAGAI DAICHI (JP)
SENO CHIEKO (JP)
YAMAMOTO KEIICHIROU (JP)
SAITO YUSUKE (JP)
MOCHIZUKI AYAKA (JP)
KAMIMURA KAZUYA (JP)

Application Number:

PCT/JP2015/070785

Publication Date:

February 11, 2016

Filing Date:

July 22, 2015

Export Citation:

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Assignee:

NIPPON KAYAKU KK (JP)

International Classes:

A61K45/00; A61K31/7068; A61K47/48; A61P31/12; A61P35/00; A61P43/00

Domestic Patent References:

WO2012067138A1	2012-05-24
WO2006120914A1	2006-11-16
WO2008056596A1	2008-05-15

Other References:

KUMIKO KATO ET AL.: "Evaluation of Block Copolymer Micelle Medicinal Products", PHARMACEUTICAL AND MEDICAL DEVICE REGULATORY SCIENCE, vol. 44, no. 12, 2013, pages 968 - 975

Attorney, Agent or Firm:

Kawaguti & Partners (JP)
In the patent business corporation Kawaguchi 國 case, it is a patent firm. (JP)

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