Title:
POLYCARBONATES BEARING AROMATIC N-HETEROCYCLES FOR DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2015/083377
Kind Code:
A1
Abstract:
Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
Inventors:
CHAN JULIAN M W (US)
ENGLER AMANDA C (US)
HEDRICK JAMES L (US)
KE XIYU (SG)
NG VICTOR W L (SG)
SARDON HARIZ (US)
TAN JEREMY P K (SG)
YANG YI YAN (SG)
ENGLER AMANDA C (US)
HEDRICK JAMES L (US)
KE XIYU (SG)
NG VICTOR W L (SG)
SARDON HARIZ (US)
TAN JEREMY P K (SG)
YANG YI YAN (SG)
Application Number:
PCT/JP2014/006043
Publication Date:
June 11, 2015
Filing Date:
December 03, 2014
Export Citation:
Assignee:
IBM (US)
AGENCY SCIENCE TECH & RES (SG)
UNIV PAIS VASCO (ES)
IBM JAPAN (JP)
AGENCY SCIENCE TECH & RES (SG)
UNIV PAIS VASCO (ES)
IBM JAPAN (JP)
International Classes:
A61K9/51; A61K31/704; A61K31/7088; A61K38/00; A61K47/34; C08G64/16
Domestic Patent References:
| WO2011078803A1 | 2011-06-30 | |||
| WO2011135046A1 | 2011-11-03 |
Foreign References:
| KR20140133738A | 2014-11-20 | |||
| JP2007293222A | 2007-11-08 |
Other References:
SANDERS, D.P. ET AL.: "A Simple and Efficient Synthesis of Functionalized Cyclic Carbonate Monomers Using a Versatile Pentafluorophenyl Ester Intermediate", J. AM. CHEM. SOC., vol. 132, no. 42, 27 October 2010 (2010-10-27), pages 14724 - 14726, XP055242220, DOI: 10.1021/JA105332K
MINDEMARK, J. ET AL.: "Diversity in cyclic carbonates: synthesis of triazole-functional monomers using click chemistry", POLYM. CHEM., vol. 3, 2012, pages 1399 - 1401, XP055348470, DOI: 10.1039/C2PY20152F
ATTIA, AB. ET AL.: "The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles", BIOMATERIALS, vol. 34, 4 February 2013 (2013-02-04), pages 3132 - 3140, XP028971184, DOI: 10.1016/J.BIOMATERIALS.2013.01.042
YANG, C. ET AL.: "The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles", BIOMATERIALS, vol. 33, no. 10, 2012, pages 2971 - 2979, XP028888708, DOI: 10.1016/J.BIOMATERIALS.2011.11.035
See also references of EP 3076955A4
MINDEMARK, J. ET AL.: "Diversity in cyclic carbonates: synthesis of triazole-functional monomers using click chemistry", POLYM. CHEM., vol. 3, 2012, pages 1399 - 1401, XP055348470, DOI: 10.1039/C2PY20152F
ATTIA, AB. ET AL.: "The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles", BIOMATERIALS, vol. 34, 4 February 2013 (2013-02-04), pages 3132 - 3140, XP028971184, DOI: 10.1016/J.BIOMATERIALS.2013.01.042
YANG, C. ET AL.: "The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles", BIOMATERIALS, vol. 33, no. 10, 2012, pages 2971 - 2979, XP028888708, DOI: 10.1016/J.BIOMATERIALS.2011.11.035
See also references of EP 3076955A4
Attorney, Agent or Firm:
MAYAMA, Shinya (4th-Floor Den-entoshi Construction Bldg.,5-9, Chuorinkan 4-chome, Yamato-sh, Kanagawa 07, JP)
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