Title:
POLYCYCLIC BIOREGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/089514
Kind Code:
A1
Abstract:
A polycyclic bioregulator, a preparation method therefor and an application thereof. In particular, the present invention relates to a compound represented by general formula (II) or a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition comprising the compound, and an application thereof in the preparation of a drug for treating cancer and other related diseases.
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Inventors:
GAO PENG (CN)
SUN GUANGJUN (CN)
WANG SHAOBAO (CN)
XIU WENHUA (CN)
TAN SONGLIANG (CN)
BAO RUDI (CN)
SUN GUANGJUN (CN)
WANG SHAOBAO (CN)
XIU WENHUA (CN)
TAN SONGLIANG (CN)
BAO RUDI (CN)
Application Number:
PCT/CN2021/126948
Publication Date:
May 05, 2022
Filing Date:
October 28, 2021
Export Citation:
Assignee:
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D491/048; A61K31/5377; A61P35/00; C07D333/78; C07D519/00
Foreign References:
| CN108601788A | 2018-09-28 | |||
| CN110891567A | 2020-03-17 | |||
| US20120238766A1 | 2012-09-20 |
Other References:
ERNST, J. ET AL.: "Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, 29 May 2020 (2020-05-29), pages 5879 - 5955, XP055890843, DOI: 10.1021/acs.jmedchem.0c00182
LIU, T. ET AL.: "Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, 1 October 2012 (2012-10-01), pages 8859 - 8878, XP055160304, DOI: 10.1021/jm3011542
LIU, T. ET AL.: "Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, 1 October 2012 (2012-10-01), pages 8859 - 8878, XP055160304, DOI: 10.1021/jm3011542
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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