Title:
POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/083162
Kind Code:
A1
Abstract:
The present invention relates to the technical field of drug for the treatment of AIDS. Disclosed are a polycyclic carbamoyl pyridone derivative, a preparation method therefor, and a pharmaceutical composition thereof. The derivative comprises the compound represented by formula (I)-1 or formula (I)-2, and an isomer, pharmaceutically acceptable salt, hydrate or solvate thereof. At least one of the functional groups in (1)-(3) below and a ring A form a spirocycle or a spiroheterocycle: (1) R1 and R2; (2) R3 and R4; (3) R5 and R6; the polycyclic carbamoyl pyridone derivative can selectively inhibit the activity of HIV integrase, and thus can be used for preventing and treating AIDS.
Inventors:
SHI YIAN (CN)
TIAN ZONGYONG (CN)
CHEN LULU (CN)
HU TIANJIN (CN)
FU HELIANG (CN)
TIAN ZONGYONG (CN)
CHEN LULU (CN)
HU TIANJIN (CN)
FU HELIANG (CN)
Application Number:
PCT/CN2022/130550
Publication Date:
May 19, 2023
Filing Date:
November 08, 2022
Export Citation:
Assignee:
NANJING AIDEA PHARMACEUTICAL TECH CO LTD (CN)
JIANGSU AIDEA PHARMACEUTICAL CO LTD (CN)
JIANGSU AIDEA PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D498/20; A61K31/537; A61P31/18
Domestic Patent References:
| WO2006116764A1 | 2006-11-02 |
Foreign References:
| CN114230579A | 2022-03-25 | |||
| CN112521386A | 2021-03-19 |
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
Download PDF: