POLYCYCLIC COMPOUND AND USE THEREOF

Title:

POLYCYCLIC COMPOUND AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/217156

Kind Code:

A1

Abstract:

A polycyclic compound, a preparation method therefor, and the use thereof in the prevention and/or treatment of proliferative diseases. The compound has a structure as represented by formula (I):

Inventors:

LIANG APENG (CN)
LIU GUANGBIN (CN)
CHEN SHAOQING (CN)
LI JUN (CN)
WU YUSHENG (CN)
YIN ZHOU (CN)
DONG SHENGLI (CN)
NIU CHENGSHAN (CN)
LI MEIHUA (CN)

Application Number:

PCT/CN2023/093095

Publication Date:

November 16, 2023

Filing Date:

May 09, 2023

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Assignee:

TYK MEDICINES INC (CN)

International Classes:

C07D401/04; A61K31/44; A61P35/00; C07D401/14

Domestic Patent References:

WO2018014880A1	2018-01-25
WO2009081259A1	2009-07-02
WO2010077992A1	2010-07-08
WO2019222538A1	2019-11-21
WO2019089626A1	2019-05-09

Foreign References:

CN102300860A	2011-12-28
CN103814016A	2014-05-21
CN102250022A	2011-11-23

Other References:

TALMON MARIA ET AL.: "Design, Synthesis and Biological Evaluation of Vortioxetine Derivatives as New COX-1/2 Inhibitors in Human Monocytes", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 28, no. 23, 11 September 2020 (2020-09-11), XP086403194, ISSN: 1464-3391, DOI: 10.1016/j.bmc.2020.115760
DATABASE REGISTRY 14 September 2017 (2017-09-14), ANONYMOUS: "2-Buten-1-one, 4-(dimethylamino)-1-[4-[3-[(3-methyl-2-pyridinyl)amino]-2- pyrazinyl]-1-piperidinyl]- (CA INDEX NAME)", XP093108525, retrieved from STNext Database accession no. 2127383-47-3

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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