POLY(DIALLYLAMINE)-BASED BILE ACID SEQUESTRANTS

WIPO Patent Application WO1998029107

A3

The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.

HOLMES-FARLEY STEPHEN RANDALL (US)
DHAL PRADEEP K (US)
PETERSEN JOHN S (US)

PCT/US1997/023899

March 01, 2001

December 29, 1997

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GELTEX PHARMA INC (US)
HOLMES FARLEY STEPHEN RANDALL (US)
DHAL PRADEEP K (US)
PETERSEN JOHN S (US)

A61K31/785; A61K31/787; A61K31/795; A61K47/48; A61P3/06; A61P9/10; A61P43/00; C08F26/04; C08G61/12; (IPC1-7): A61K31/14

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JPS62257481A	1987-11-10
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US4360434A	1982-11-23
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MCLEAN ET AL.: "Cyclopolymerization. VI. Preparation and properties of Crosslinked Polyamines by Cyclopolymerization", J. MACROMOL. SCI.-CHEM., vol. A10, no. 5, 1976, pages 857 - 873, XP002068701
BOLTO ET AL.: "Synthesis of Cross-Linked Polyallylamines Which Are Resistant to Sulfite Attack", J. MACROMOL. SCI.-CHEM., vol. A17, no. 1, 1982, pages 153 - 166, XP002068702

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