POLYDISULFIDE POLYPEPTIDE NANOPARTICLE, PREPARATION METHOD THEREFOR, AND POLYPEPTIDE DRUG ORAL PREPARATION

Title:

POLYDISULFIDE POLYPEPTIDE NANOPARTICLE, PREPARATION METHOD THEREFOR, AND POLYPEPTIDE DRUG ORAL PREPARATION

Document Type and Number:

WIPO Patent Application WO/2023/065550

Kind Code:

A1

Abstract:

The present invention provides a polydisulfide polypeptide nanoparticle, which is a nanoparticle formed by assembling a disulfide heterocyclic compound and a polypeptide drug. The disulfide heterocyclic compound has a structure as shown in formula I. The present invention solves the problems that the existing polypeptide drug administration mode is single and other polypeptide oral delivery technologies have defects. The prepared polydisulfide polypeptide nanoparticle is simple in preparation method and convenient to use, can overcome three barriers of oral administration, and has high bioavailability.

More Like This:

WO/2001/085216	METHOD FOR THE PREPARATION OF POLYMERIC MICELLE VIA PHASE SEPARATION OF BLOCK COPOLYMER
JP6454008	Nanocapsules for local drug delivery system into cells using mutant chaperonin complex
WO/2020/036324	MAGNETIC-FIELD-DRIVEN MICROSTRUCTURE FOR DELIVERING DRUG, AND METHOD FOR PRODUCING SAME

Inventors:

CHEN ZHAOWEI (CN)
LIU ZHENG (CN)
YANG HUANGHAO (CN)
CHEN CHEN (CN)
HE YU (CN)

Application Number:

PCT/CN2022/072014

Publication Date:

April 27, 2023

Filing Date:

January 14, 2022

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV FUZHOU (CN)

International Classes:

A61K9/51; A61K45/06; A61K47/54; B82Y5/00; B82Y40/00

Foreign References:

CN105727307A	2016-07-06
CN109758588A	2019-05-17

Other References:

XIE, YANGYANG ET AL.: "Advances in the research and application of cell penetrating peptides", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 35, no. 7, 25 July 2019 (2019-07-25), pages 1162 - 1173, XP009545378
GASPARINI GIULIO, BANG EUN-KYOUNG, MOLINARD GUILLAUME, TULUMELLO DAVID V., WARD SANDRA, KELLEY SHANA O., ROUX AURELIEN, SAKAI NAOM: "Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 16, 23 April 2014 (2014-04-23), pages 6069 - 6074, XP055860766, ISSN: 0002-7863, DOI: 10.1021/ja501581b

Attorney, Agent or Firm:

UNITALEN ATTORNEYS AT LAW (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: SEMICONDUCTOR DEVICE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Next Patent: AGGREGATE FORMED BY MEANS OF ASSEMBLING CHALCOGEN HETEROCYCLIC COMPOUND AND INSULIN, AND PREPARATION...