Title:
POLYENE COMPOUND, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/192564
Kind Code:
A1
Abstract:
Disclosed are a polyene compound, preparation method and use thereof. Provided in the present invention is the preparation method of a polyene compound I, comprising the following steps: under an action of a base and in an organic solvent, conducting a Witting reaction on a compound II and a compound III to obtain the polyene compound I. By the preparation method in the present invention, a coupling reaction results in good product purity without producing an obvious by-product and involves no heavy metal, thus facilitating a control over product quality and costs, having a simple operation and mild reaction condition, enabling high reaction conversion, a high yield, few by-products, high resultant product purity, low production costs and simple post-processing, and being suitable for industrial production.
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Inventors:
WANG MENG (CN)
WANG DONG (CN)
WANG FANGDAO (CN)
CAI MAOJUN (CN)
ZHOU JIE (CN)
WANG DONG (CN)
WANG FANGDAO (CN)
CAI MAOJUN (CN)
ZHOU JIE (CN)
Application Number:
PCT/CN2016/083427
Publication Date:
December 08, 2016
Filing Date:
May 26, 2016
Export Citation:
Assignee:
CHEMVON BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07F7/18; C07C401/00
Foreign References:
| CN101316813A | 2008-12-03 | |||
| CN1436170A | 2003-08-13 |
Other References:
SHIMIZU, K. ET AL.: "Design and Evaluation of New Atipsoriatic Antedrug Candidates Having 16-en-22-oxa-vitamin D3 structures", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 12, 21 April 2006 (2006-04-21), pages 3323 - 3329, XP027965606
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
上海弼兴律师事务所 (CN)
上海弼兴律师事务所 (CN)
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