Title:
POLYENE DIESTER ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2009/015541
Kind Code:
A1
Abstract:
The present invention discloses novel polyene diesters of formula 1 and their
preparation. The diesters are used as prodrugs by introducing diester group
to polyene antibiotics, which exhibit antifungal or antiviral activity through
releasing parent polyenes by esterase in vivo. These new derivatives have good
antimicrobial activity and better safety. These new derivatives are useful
for the antifungal and antiviral treatment. PA-COOR Formula 1
Inventors:
WANG WENMEI (CN)
WANG SHUHUI (CN)
LI JI AN (CN)
WANG SHUHUI (CN)
LI JI AN (CN)
Application Number:
PCT/CN2007/070382
Publication Date:
February 05, 2009
Filing Date:
July 30, 2007
Export Citation:
Assignee:
SHANGHAI INST PHARM INDUSTRY (CN)
WANG WENMEI (CN)
WANG SHUHUI (CN)
LI JI AN (CN)
WANG WENMEI (CN)
WANG SHUHUI (CN)
LI JI AN (CN)
International Classes:
A61K31/7048; C07H17/08; A61P31/10; A61P31/18
Domestic Patent References:
| WO2001051061A1 | 2001-07-19 | |||
| WO2001091758A1 | 2001-12-06 |
Foreign References:
| CN101081860A | 2007-12-05 | |||
| US5981721A | 1999-11-09 |
Other References:
See also references of EP 2174944A4
None
None
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (Xuhui, Shanghai 3, CN)
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