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Title:
POLYETHYLENE GLYCOL -CACTUS OLIGOPEPTIDE BONDING RAPAMYCIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2015/081821
Kind Code:
A1
Abstract:
The present invention provides compounds represented by formula (I) and pharmaceutical acceptable salts thereof, preparation method therefor and pharmaceutical composition containing the compounds represented by formula (I) and pharmaceutical acceptable salts thereof. In the compounds of the present invention, each terminal group of polyethylene glycol molecule can bond with a plurality of rapamycin molecules by cactus oligopeptide, with the loading rate of the pharmaceutical being increased. The compounds can be used to induce immunosuppression and treat graft rejection, autoimmune disease, solid tumors, fungal infection, and cardiovascular and cerebrovascular disease.

Inventors:
JIA, Jianhuan (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
FENG, Zewang (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
WANG, Jinliang (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
LIU, Yan (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
WANG, Zhenguo (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
ZHAO, Xuan (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
Application Number:
CN2014/092646
Publication Date:
June 11, 2015
Filing Date:
December 01, 2014
Export Citation:
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Assignee:
JENKEM TECHNOLOGY CO., LTD. (BEIJING) (Building C-1, 3/F Zhongguancun Dongsheng Science Park, 66 Xi Xiaokou Road, Haidian District, Beijing 2, 100192, CN)
International Classes:
C08G65/333; C07D498/18; C08G65/331
Foreign References:
CN103083680A2013-05-08
CN1367787A2002-09-04
US20110224383A12011-09-15
Attorney, Agent or Firm:
SBZL IP LAW OFFICE (Suite 901, 9th floor No. 1 Zhichun Road, Haidian District, Beijing 3, 100083, CN)
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