Title:
POLYETHYLENE GLYCOL MODIFIED BODY FOR HEPATOCYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/158691
Kind Code:
A1
Abstract:
An objective of the present invention is to provide a variant of a hepatocyte growth factor or active fragment thereof capable of lowering liver tropism and selectively expressing bioactivity in target disease tissue other than liver tissue. The present invention provides a polyethylene glycol modified body, of a hepatocyte growth factor or an active fragment thereof, in which polyethylene glycol is bound, via a protease-sensitive peptide, to the terminus of the hepatocyte growth factor or active fragment thereof.
Inventors:
SERIZAWA TAKASHI (JP)
MORI KATSUYUKI (JP)
ASANO TOMOMI (JP)
SATO MIKIYA (JP)
MORI KATSUYUKI (JP)
ASANO TOMOMI (JP)
SATO MIKIYA (JP)
Application Number:
PCT/JP2020/002864
Publication Date:
August 06, 2020
Filing Date:
January 28, 2020
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
A61P43/00; A61K38/18; A61K47/60; A61K47/65; C07K14/475; C07K17/10; C07K19/00
Domestic Patent References:
| WO1996028475A1 | 1996-09-19 | |||
| WO2002074344A2 | 2002-09-26 | |||
| WO1996028475A1 | 1996-09-19 | |||
| WO1987000056A1 | 1987-01-15 | |||
| WO1999055377A2 | 1999-11-04 |
Foreign References:
| JP2010174034A | 2010-08-12 | |||
| US4917888A | 1990-04-17 | |||
| JP2009207490A | 2009-09-17 |
Other References:
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SAKATA H. ET AL., CELL GROWTH & DIFFERENTIATION, vol. 7, 1996, pages 1513 - 1523
JAKUBCZAK J.L. ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 3, 1998, pages 1275 - 1283
OTSUKA T. ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 6, 2000, pages 2055 - 2065
DATE K. ET AL., FEBS LETTERS, vol. 420, no. 1, 1997, pages 1 - 6
ROSS J. ET AL., GASTROENTEROLOGY, vol. 142, 2012, pages 897 - 906
STEFAN N. ET AL., BIOCONJUGATE CHEMISTRY, vol. 25, 2014, pages 2144 - 2156
MIYAZAWA K. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 7, 1996, pages 3615 - 3618
KINOSAKI M. ET AL., FEBS LETTERS, vol. 434, 1998, pages 165 - 170
ALTSCHUL S. ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 215, no. 3, 1990, pages 403 - 410
ALTSCHUL S. ET AL., NUCLEIC ACIDS RESEARCH, vol. 25, no. 17, 1997, pages 3389 - 3402
DATE K. ET AL., FEBS LETTER, vol. 420, no. 1, 1997, pages 1 - 6
LIETHA D. ET AL., THE EMBO JOURNAL, vol. 20, no. 20, 2001, pages 5543 - 5555
MELENHORST W.B. ET AL., AMERICAN JOURNAL OF PHYSIOLOGY, vol. 297, no. 3, 2009, pages 781 - 790
DAVID C.J.H. ET AL., AMERICAN JOURNAL OF PHYSIOLOGY, vol. 159, no. 4, 2001, pages 1383 - 1393
JUNWEI Y. ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 110, 2002, pages 1525 - 1538
ALDO B. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, 2003, pages 25933 - 25939
BELEN S.J. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, 2007, pages 8325 - 8331
CAESCU C.I. ET AL., BIOCHEMICAL JOURNAL, vol. 424, 2009, pages 79 - 88
MAIKE G. ET AL., PLOS ONE, vol. 7, 2012, pages E31756 - 31771
BO C. ET AL., THE JOURNAL OF NEUROSCIENCE, vol. 32, no. 22, 2012, pages 7622 - 7631
INADA ET AL., JOURNAL OF BIOACT AND COMPATIBLE POLYMERS, vol. 5, 1990, pages 343
DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249
KATRE, ADVANCED DRUG DELIVERY SYSTEMS, vol. 10, 1993, pages 91
SUNDQVIST T. ET AL., COMPUTERS AND BIOMEDICAL RESEARCH, vol. 21, no. 2, 1988, pages 110 - 116
"Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 5743 - 5745
RUBIN J.S. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 35, 2001, pages 32977 - 32983
LIU Y. ET AL., AMERICAN JOURNAL OF PHYSIOLOGY, vol. 277, no. 4, 1999, pages 624 - 633
LIU K.X. ET AL., THE AMERICAN JOURNAL OF PHYSIOLOGY, vol. 275, 1998, pages E835 - E842
SAKATA H. ET AL., CELL GROWTH & DIFFERENTIATION, vol. 7, 1996, pages 1513 - 1523
JAKUBCZAK J.L. ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 3, 1998, pages 1275 - 1283
OTSUKA T. ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 6, 2000, pages 2055 - 2065
DATE K. ET AL., FEBS LETTERS, vol. 420, no. 1, 1997, pages 1 - 6
ROSS J. ET AL., GASTROENTEROLOGY, vol. 142, 2012, pages 897 - 906
STEFAN N. ET AL., BIOCONJUGATE CHEMISTRY, vol. 25, 2014, pages 2144 - 2156
MIYAZAWA K. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 7, 1996, pages 3615 - 3618
KINOSAKI M. ET AL., FEBS LETTERS, vol. 434, 1998, pages 165 - 170
ALTSCHUL S. ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 215, no. 3, 1990, pages 403 - 410
ALTSCHUL S. ET AL., NUCLEIC ACIDS RESEARCH, vol. 25, no. 17, 1997, pages 3389 - 3402
DATE K. ET AL., FEBS LETTER, vol. 420, no. 1, 1997, pages 1 - 6
LIETHA D. ET AL., THE EMBO JOURNAL, vol. 20, no. 20, 2001, pages 5543 - 5555
MELENHORST W.B. ET AL., AMERICAN JOURNAL OF PHYSIOLOGY, vol. 297, no. 3, 2009, pages 781 - 790
DAVID C.J.H. ET AL., AMERICAN JOURNAL OF PHYSIOLOGY, vol. 159, no. 4, 2001, pages 1383 - 1393
JUNWEI Y. ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 110, 2002, pages 1525 - 1538
ALDO B. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, 2003, pages 25933 - 25939
BELEN S.J. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, 2007, pages 8325 - 8331
CAESCU C.I. ET AL., BIOCHEMICAL JOURNAL, vol. 424, 2009, pages 79 - 88
MAIKE G. ET AL., PLOS ONE, vol. 7, 2012, pages E31756 - 31771
BO C. ET AL., THE JOURNAL OF NEUROSCIENCE, vol. 32, no. 22, 2012, pages 7622 - 7631
INADA ET AL., JOURNAL OF BIOACT AND COMPATIBLE POLYMERS, vol. 5, 1990, pages 343
DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249
KATRE, ADVANCED DRUG DELIVERY SYSTEMS, vol. 10, 1993, pages 91
SUNDQVIST T. ET AL., COMPUTERS AND BIOMEDICAL RESEARCH, vol. 21, no. 2, 1988, pages 110 - 116
"Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 5743 - 5745
RUBIN J.S. ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 35, 2001, pages 32977 - 32983
LIU Y. ET AL., AMERICAN JOURNAL OF PHYSIOLOGY, vol. 277, no. 4, 1999, pages 624 - 633
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