Title:
POLYETHYLENE GLYCOL MODIFIED INTERFERON ALPHA 2B AND PREPARATION METHOD AND APPLICATIOINS THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/030066
Kind Code:
A1
Abstract:
Provided are mono-modified interferon alpha 2b by Y-type branched polyethylene
glycol at the specific lysine position and the preparation method thereof. The
pegylated interferon alpha 2b can be used for manufacture of pharmaceutical
composition for treating diseases such as viral infection like hepatitis C etc.
Inventors:
ZHOU WEIDONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
YIN FENGHONG (CN)
LUO SHIHONG (CN)
ZHUANG LU (CN)
LIU MIN (CN)
XU TIANLE (CN)
ZHANG YONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
YIN FENGHONG (CN)
LUO SHIHONG (CN)
ZHUANG LU (CN)
LIU MIN (CN)
XU TIANLE (CN)
ZHANG YONG (CN)
Application Number:
PCT/CN2007/002644
Publication Date:
March 12, 2009
Filing Date:
September 04, 2007
Export Citation:
Assignee:
BIOSTEED GENE EXPRESSION TECH (CN)
ZHOU WEIDONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
YIN FENGHONG (CN)
LUO SHIHONG (CN)
ZHUANG LU (CN)
LIU MIN (CN)
XU TIANLE (CN)
ZHANG YONG (CN)
ZHOU WEIDONG (CN)
XIAO QINGJIANG (CN)
SUN LI (CN)
WANG TIEBING (CN)
YIN FENGHONG (CN)
LUO SHIHONG (CN)
ZHUANG LU (CN)
LIU MIN (CN)
XU TIANLE (CN)
ZHANG YONG (CN)
International Classes:
C07K17/08; A61K47/48; A61P11/06; A61P19/02; A61P29/00; A61P31/12; A61P35/00; A61K38/21; C07K14/56
Domestic Patent References:
| WO2003076490A1 | 2003-09-18 |
Foreign References:
| CN1711109A | 2005-12-21 | |||
| US4179337A | 1979-12-18 | |||
| EP0593868A1 | 1994-04-27 | |||
| EP0809996A2 | 1997-12-03 | |||
| CN1243779C | 2006-03-01 | |||
| US0103411A | 1870-05-24 |
Other References:
WANG YUSEN ET AL.: "Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications, cited in the application", ADVANCED DRUG DELIVERY REVIEWS, vol. 54, no. 4, 2002, pages 547 - 570, XP002989691
GRACE M. ET AL.: "Structural and biologic characterization of pegylated recombinant IFN-a 2b", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, vol. 21, no. 12, 2001, pages 1103 - 1115, XP002425931
KENJI ORITANI; PAUL W KINCADE ET AL.: "Type I interferon and limitin: a comparison of structures, receptors, and functions", CYTOKINE AND GROWTH FACTOR REVIEWS, vol. 12, 2001, pages 337 - 348
YU-SEN WANG; STEPHEN YOUNGSTER ET AL.: "Structural and biological characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implications", ADVANCE DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570, XP002989691, DOI: doi:10.1016/S0169-409X(02)00027-3
HENCO K.; BROSIUS F.J. ET AL., J. MOL. BIOL., vol. 185, 1985, pages 227 - 260
INADA ET AL., J. BIOACT. AND COMPATIBLE POLYMERS, vol. 5, 1990, pages 343
DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249
KATRE, ADVANCED DRUG DELIVERY SYSTEMS, vol. 10, 1993, pages 91
SATAKE-ISHIKAWA ET AL., CELL STRUCTURE AND FUNCTION, vol. 17, 1992, pages 157 - 160
KATRE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1487
TSUTSUMI ET AL., JPN. J. CANCER RES., vol. 85, 1994, pages 9
INOUE ET AL., J. LAB. CLIN. MED., vol. 124, 1994, pages 529
CHAMOW ET AL., BIOCONJ. CHEM., vol. 5, 1994, pages 133
MONFARDINI ET AL., BIOCONJUGATE CHEM., vol. 6, 1995, pages 62
YU-SEN WANG ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570
YU-SEN WANG ET AL., BIOCHEMISTRY, vol. 39, 2000, pages 10634 - 10640
LAEMMLI ET AL., NATURE, vol. 227, 1970, pages 680
PHARMACOPOEIA OF THE PEOPLE'S REPUBLIC OF CHINA, vol. 3, 2005
GRACE M. ET AL.: "Structural and biologic characterization of pegylated recombinant IFN-a 2b", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, vol. 21, no. 12, 2001, pages 1103 - 1115, XP002425931
KENJI ORITANI; PAUL W KINCADE ET AL.: "Type I interferon and limitin: a comparison of structures, receptors, and functions", CYTOKINE AND GROWTH FACTOR REVIEWS, vol. 12, 2001, pages 337 - 348
YU-SEN WANG; STEPHEN YOUNGSTER ET AL.: "Structural and biological characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implications", ADVANCE DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570, XP002989691, DOI: doi:10.1016/S0169-409X(02)00027-3
HENCO K.; BROSIUS F.J. ET AL., J. MOL. BIOL., vol. 185, 1985, pages 227 - 260
INADA ET AL., J. BIOACT. AND COMPATIBLE POLYMERS, vol. 5, 1990, pages 343
DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249
KATRE, ADVANCED DRUG DELIVERY SYSTEMS, vol. 10, 1993, pages 91
SATAKE-ISHIKAWA ET AL., CELL STRUCTURE AND FUNCTION, vol. 17, 1992, pages 157 - 160
KATRE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1487
TSUTSUMI ET AL., JPN. J. CANCER RES., vol. 85, 1994, pages 9
INOUE ET AL., J. LAB. CLIN. MED., vol. 124, 1994, pages 529
CHAMOW ET AL., BIOCONJ. CHEM., vol. 5, 1994, pages 133
MONFARDINI ET AL., BIOCONJUGATE CHEM., vol. 6, 1995, pages 62
YU-SEN WANG ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 547 - 570
YU-SEN WANG ET AL., BIOCHEMISTRY, vol. 39, 2000, pages 10634 - 10640
LAEMMLI ET AL., NATURE, vol. 227, 1970, pages 680
PHARMACOPOEIA OF THE PEOPLE'S REPUBLIC OF CHINA, vol. 3, 2005
Attorney, Agent or Firm:
NTD PATENT & TRADEMARK AGENCY LIMITED BEIJING OFFICE (Block A Investment Plaza, 27 Jinrongdajie, Beijing 2, CN)
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