Title:
POLYETHYLENE GLYCOL MONOMETHYL ETHER-POLYLACTIC ACID COPOLYMER, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/083265
Kind Code:
A1
Abstract:
A preparation method for a polyethylene glycol monomethyl ether-polylactic acid copolymer. According to the method, the molecular weight and characteristics of a final product are adjusted by means of controlling the feed ratio of a polyethylene glycol derivative to a lactide; a copolymer with a more uniform molecular weight distribution is obtained by means of controlling the water content of a starting material; and tin is adsorbed and removed by using a high-purity sulfydryl-modified silica gel. The method has the characteristics of a simple and convenient operation and a low cost, can reach the level where heavy metal residues are not detected, and is particularly suitable for large-scale industrial scaled-up production. A polyethylene glycol monomethyl ether-polylactic acid copolymer prepared by using the above-mentioned method can be used as a carrier for a hydrophobic drug or used for preparing a medical cosmetology product.
Inventors:
YAN RUIGUO (CN)
WANG SHUANG (CN)
YANG QUANFEI (CN)
LIU ZHE (CN)
WU QIUHONG (CN)
WANG SHUANG (CN)
YANG QUANFEI (CN)
LIU ZHE (CN)
WU QIUHONG (CN)
Application Number:
PCT/CN2022/131171
Publication Date:
May 19, 2023
Filing Date:
November 10, 2022
Export Citation:
Assignee:
BEIJING MEIYAN SPACE BIOMEDICINE CO LTD (CN)
International Classes:
A43B13/02; C08G63/08; B29B9/12; C08G63/66; C08G63/664; C08G63/90; C08L51/06
Domestic Patent References:
| WO2017190115A1 | 2017-11-02 |
Foreign References:
| CN104961886A | 2015-10-07 | |||
| CN105315444A | 2016-02-10 | |||
| CN111978520A | 2020-11-24 | |||
| CN104892909A | 2015-09-09 | |||
| CN106995528A | 2017-08-01 | |||
| CN103601878A | 2014-02-26 | |||
| CN104761710A | 2015-07-08 | |||
| CN102219892A | 2011-10-19 | |||
| KR20030059607A | 2003-07-10 |
Attorney, Agent or Firm:
BEIJING LINKAW PATENT ATTORNEY LAW FIRM (CN)
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