POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS

Title:

POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2015/165279

Kind Code:

A1

Abstract:

Provided are new polyfluoro-substituted pyrazolopyrimidine compounds or salts represented by formulae (I) to (IX), a preparation method therefor, and a method for using said compounds and a preparation thereof to treat and inhibit autoimmune diseases or disorders, heteroimmune diseases or disorders, inflammatory diseases and cancers or disorders.

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Inventors:

HE WEI (CN)

Application Number:

PCT/CN2015/000290

Publication Date:

November 05, 2015

Filing Date:

April 27, 2015

Export Citation:

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Assignee:

ZHEJIANG DTRM BIOPHARMA (CN)

International Classes:

C07D487/04; A61K31/519; A61P1/04; A61P1/16; A61P3/10; A61P5/20; A61P11/00; A61P11/06; A61P17/00; A61P17/10; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; C07C43/29; C07C45/29; C07C49/813; C07C303/38; C07C311/08; C07D213/81; C07D215/22; C07D215/233; C07D239/34; C07D519/00; C07F5/04

Domestic Patent References:

WO2013191965A1	2013-12-27
WO2014022569A1	2014-02-06

Foreign References:

CN103534258A	2014-01-22
US8673925B1	2014-03-18
CN102656173A	2012-09-05

Other References:

LEVY, A. ET AL.: "Dications of Fluorenylidenes. The Effect of Substituent Electronegativity and Position on the Antiaromaticity of Substituted Tetrabenzo [5.5] Fulvalene Dications", J. ORG. CHEM., vol. 68, no. 10, 16 May 2003 (2003-05-16), pages 3990 - 3998, XP055234354, ISSN: 0022-3263
See also references of EP 3138842A4

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