Title:
POLYHYDROXY-1,4-NAPHTHOQUINONES AND A PHARMACEUTICAL PREPARATION AS PROTECTOR OF MYOCARDIUM UNDER ISCHEMIA AND REPERFUSION BASED ON THEM
Document Type and Number:
WIPO Patent Application WO/1991/008189
Kind Code:
A1
Abstract:
Polyhydroxy-1,4-naphthoquinones of general formula (I), where, with R1 = R2 = hydroxy group, R3 = tret.butyl and R4 = hydrogen, or R3 = hydroxy group and R4 = propyl or 2-carboxyethyl; with R1 = R2 = 2-hydroxyethyl group, R3 = hydroxy group and R4 = methyl; with R1 = R2 = glutathionyl, R3 = hydroxy group and R4 = methyl or ethyl or a hydroxy group. The claimed compositions have the property of protector of the myocardium under ischemia and reperfusion. The most active compositions are 2,3,5,6,8-pentahydroxy-7-(2-carboxyethyl)-1,4-naphthoquinone and 5,6,8-trihydroxy-2,3-diglutathionyl-7-methyl-1,4-naphthoquinone. Polyhydroxy-1,4-naphthoquinones are the active substances of the claimed pharmaceutical preparation.
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Inventors:
NOVIKOV VYACHESLAV LEONIDOVICH (SU)
ANUFRIEV VIKTOR FILIPPOVICH (SU)
LEVITSKY DMITRY OLEGOVICH (SU)
LEBEDEV ALEXANDR VLADIMIROVICH (SU)
SADRETDINOV SAFA MYALIKOVICH (SU)
SHVILKIN ALEXEI VLADIMIROVICH (SU)
AFONSKAYA NATALYA IVANOVNA (SU)
RUDA MIKHAIL YAKOVLEVICH (SU)
CHERPACHENKO NINA MIKAILOVNA (SU)
MAXIMOV OLEG BORISOVICH (SU)
ELYAKOV GEORGY BORISOVICH (SU)
ANUFRIEV VIKTOR FILIPPOVICH (SU)
LEVITSKY DMITRY OLEGOVICH (SU)
LEBEDEV ALEXANDR VLADIMIROVICH (SU)
SADRETDINOV SAFA MYALIKOVICH (SU)
SHVILKIN ALEXEI VLADIMIROVICH (SU)
AFONSKAYA NATALYA IVANOVNA (SU)
RUDA MIKHAIL YAKOVLEVICH (SU)
CHERPACHENKO NINA MIKAILOVNA (SU)
MAXIMOV OLEG BORISOVICH (SU)
ELYAKOV GEORGY BORISOVICH (SU)
Application Number:
PCT/SU1990/000267
Publication Date:
June 13, 1991
Filing Date:
December 06, 1990
Export Citation:
Assignee:
TIKHOOKEANSKY INST BIOORG KHIM (SU)
VSESOJUZNYJ KARDIOLOGITSCHES (SU)
VSESOJUZNYJ KARDIOLOGITSCHES (SU)
International Classes:
A61K31/122; A61P9/10; C07C50/32; C07C69/95; C07C323/60; (IPC1-7): A61K31/12; A61K31/22; C07C50/32; C07C323/17; C07C323/60
Foreign References:
| US4436753A | 1984-03-13 | |||
| GB2159056A | 1985-11-27 |
Other References:
IZVESTIA AKADEMII NAUK SSSR, seria Kchimicheskaya, No. 2, 1988, Nauka (Moscow), L.V. BAGUSLAVSKAYA et al.: "O Kinetike Nizkotemperaturnogo Initsiirovannogo Okislenia Etilbenzola, Ingibirovannogo Poligidroksinaftokhinomai", page 283.
TETRAHEDRON, THE INTERNATIONAL JOURNAL OF ORGANIC CHEMISTRY, Volume 23, No. 8, 1967, PERGAMON PRESS, (London, New York, Paris), R.E. MOORE et al.: "Polyhydroxynapththoquinones Preparation and Hydrolysis of Methoxyl Derivatives", pages 3271-3273.
HELVETICA CHIMICA ACTA, ENDENDA CURAT SOCIETAS CHIMICA HELVETICA, Volume 47, No. 7, 1964, VERLAG HELVETICA CHIMICA ACTA (Basel), E. HARDEGGER et al.: "Bicyclische Zwischenprodukte zur Synthese des Javanicins", pages 2017-2021.
IZVESTIA AKADEMII NAUK SSSR, seria Khimicheskaya, No. 7, 1985, Nauka (Moscow), L.V. BAGUSLAVSKAYA et al.: "Poligidroksinaftokhinonynovyi Klass Prirodnykh Antioksidantov", page 1471.
TETRAHEDRON, THE INTERNATIONAL JOURNAL OF ORGANIC CHEMISTRY, Volume 23, No. 8, 1967, PERGAMON PRESS, (London, New York, Paris), R.E. MOORE et al.: "Polyhydroxynapththoquinones Preparation and Hydrolysis of Methoxyl Derivatives", pages 3271-3273.
HELVETICA CHIMICA ACTA, ENDENDA CURAT SOCIETAS CHIMICA HELVETICA, Volume 47, No. 7, 1964, VERLAG HELVETICA CHIMICA ACTA (Basel), E. HARDEGGER et al.: "Bicyclische Zwischenprodukte zur Synthese des Javanicins", pages 2017-2021.
IZVESTIA AKADEMII NAUK SSSR, seria Khimicheskaya, No. 7, 1985, Nauka (Moscow), L.V. BAGUSLAVSKAYA et al.: "Poligidroksinaftokhinonynovyi Klass Prirodnykh Antioksidantov", page 1471.
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