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Title:
POLYHYDROXYPHTHALAZINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/214736
Kind Code:
A1
Abstract:
Provided are a polyhydroxyphthalazinone compound, a preparation method therefor and the use thereof, wherein the general formula of the chemical structure of the polyhydroxyphthalazinone compound is as shown by formula (I). The polyhydroxyphthalazinone compound disclosed in the present invention has a good ER receptor agonistic effect, and is expected to be useful in developing a novel ER receptor agonist.

Inventors:
LIANG, Faxiang (Room 604, No. 1549 Yuxi Road, Yaohai Distric, Hefei Anhui 1, 230011, CN)
DING, Yanling (Room 101, Building 18 Aolin Qinghua,Songling Town, Wujiang Distric, Suzhou Jiangsu 9, 215299, CN)
Application Number:
CN2018/086244
Publication Date:
November 29, 2018
Filing Date:
May 10, 2018
Export Citation:
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Assignee:
REJUVGEN PHARMACEUTICALS, INC. (ZHU Xinle, Room 301-550 Building 1,No. 400, Fangchun Road, Free Trade Zone, Shanghai 0, 200000, CN)
International Classes:
C07D237/32; A61K31/502; A61P1/04; A61P13/08; A61P15/00; A61P19/02; A61P19/10; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00
Foreign References:
CN107082764A2017-08-22
JPH10139640A1998-05-26
EP0475527A21992-03-18
EP1953147A12008-08-06
BE628255A
Other References:
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LAD, V. ET AL.: "Nano Ti02: a recyclable catalyst for one pot synthesis of 2-(substituted phenyl)phthalazin-1 (2H)-ones", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 7, no. 4, 31 December 2015 (2015-12-31), pages 257 - 261, XP055556880
WANG, HUAMIN ET AL.: "Palladium-Catalyzed Phthalazinone Synthesis Using Paraformaldehyde as Carbon Source", ORG. LETT., vol. 16, no. 20, 29 September 2014 (2014-09-29), pages 5324 - 5327, XP055556883
SURESH, A.S. ET AL.: "Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source", TETRAHEDRON LETTERS, vol. 55, no. 24, 1 May 2014 (2014-05-01), pages 3482 - 3485, XP055556892
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ANONYMOUS: "STNext Registry", REGISTRY (RN 931044-64-3, 11 September 2009 (2009-09-11), XP009515919, Retrieved from the Internet
YEPURU, M. ET AL.: "Estrogen receptor-beta-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 41, 8 October 2010 (2010-10-08), pages 31292 - 31303, XP055031052
Attorney, Agent or Firm:
CHANGZHOU RIGHT NAVIGATION PATENT AGENCY CO., LTD. (ZHU Xinle, Room 303-1 Building C, Tianan Digital City,No. 588, Changwu Road, Wujin Distric, Changzhou Jiangsu 4, 213164, CN)
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