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Title:
POLYMER-BASED NANOPARTICLES, RELATED FORMULATION METHODS, AND APPARATUS
Document Type and Number:
WIPO Patent Application WO/2019/139997
Kind Code:
A1
Abstract:
This invention pertains to the field of biopolymer-loaded (where the biopolymer(s) are active pharmaceutical ingredient(s) (API(s)) polymer-based nanoparticles formulated, for example, for curative, therapeutic prophylactic and/or diagnostic applications. The polymer used to formulate the nanoparticles can be any biodegradable synthetic polymer or combination of polymers, including combinations of PLGA and PEG. Biopolymers used as active pharmaceutical ingredients (API) can include natural and unnatural nucleic acids such as DNA, RNA and LNA. Biopolymers used as active pharmaceutical ingredients (APIs) can also include neutral and positively charged nucleic acid mimics (NPNAM) such as for example, peptide nucleic acids, morpholinos, pyrrolidine-amide oligonucleotide mimics, morpholinoglycine oligonucleotides and methyl phosphonates and derivatives thereof. In some embodiments, the nanoparticles are loaded with both nucleic acids and NPNAMs as the APIs. Nanoparticles so formulated can be used in curative, therapeutic, prophylactic and/or diagnostic applications. Certain preferred nanoparticles, formulation methodologies, de-formulation methodologies and apparatus are also disclosed.

Inventors:
YING BO (US)
COULL JAMES (US)
SIM DEREK (US)
Application Number:
PCT/US2019/012921
Publication Date:
July 18, 2019
Filing Date:
January 09, 2019
Export Citation:
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Assignee:
TRUCODE GENE REPAIR INC (US)
International Classes:
C12N15/11; B01F23/00; C12N15/113
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Attorney, Agent or Firm:
COLLAZO, Diana, M. et al. (US)
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