Title:
POLYMER BILE ACID RESORPTION INHIBITORS WITH SIMULTANEOUS BILE ACID ADSORBING EFFECT
Document Type and Number:
WIPO Patent Application WO1998007449
Kind Code:
A3
Abstract:
Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect are disclosed, as well as a process for preparing the same, medicaments which contain these compounds and their use. Vinyl copolymers are disclosed which contain units of formula (I), in which R<1> to R<5>, d, e, f, H, L, A, Y, Z and B have the meanings indicated in the description. Also disclosed is a process for preparing the same. These compounds are suitable for treating lipid metabolism disturbances.
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Inventors:
VON SEGGERN HEINKE (DE)
KRAMER WERNER (DE)
WESS GUENTHER (DE)
KRAMER WERNER (DE)
WESS GUENTHER (DE)
Application Number:
PCT/EP1997/004049
Publication Date:
June 25, 1998
Filing Date:
July 25, 1997
Export Citation:
Assignee:
HOECHST RES & TECH GMBH & CO (DE)
VON SEGGERN HEINKE (DE)
KRAMER WERNER (DE)
WESS GUENTHER (DE)
VON SEGGERN HEINKE (DE)
KRAMER WERNER (DE)
WESS GUENTHER (DE)
International Classes:
A61K47/48; A61K31/765; A61K31/785; A61P1/16; A61P9/10; C08F8/00; C08F12/00; C08F20/12; C08F20/54; C08F26/00; C08F246/00; (IPC1-7): A61K47/48
Foreign References:
| EP0548793A2 | 1993-06-30 | |||
| DE4234537A1 | 1994-04-21 | |||
| EP0549967A1 | 1993-07-07 | |||
| EP0489423A1 | 1992-06-10 | |||
| EP0162388A1 | 1985-11-27 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 095, no. 002 31 March 1995 (1995-03-31)
ZIEGLER ET AL.: "3'-ISOTHIOCYANATOBENZAMIDO[3H]CHOLATE, A NEW AFFINITY LABEL FOR HEPATOCELLULAR MEMBRANE PROTEINS RESPONSIBLE FOR THE UPTAKE OF BOTH BILE ACIDS AND PHALLOIDIN", BIOCHIM. BIOPHYS. ACTA, vol. 773, 1984, pages 11 - 22, XP002059739
MIYATA ET AL.: "Functional monomers and polymers. 26. Synthesis and polymerization of vinyl cholate and vinyl dehydrocholate", MAKROMOL. CHEM., vol. 176, no. 7, 1975, pages 2139 - 2142, XP002059903
DATABASE WPI Section Ch Week 9507, Derwent World Patents Index; Class A96, AN 95-048757, XP002059742
WICHMAN A.: "Affinity Chromatography of Human Plasma Low- and High-Density Lipoproteins", BIOCHEM. J., vol. 181, no. 3, 1979, pages 691 - 698, XP002059740
ZIEGLER ET AL.: "3'-ISOTHIOCYANATOBENZAMIDO[3H]CHOLATE, A NEW AFFINITY LABEL FOR HEPATOCELLULAR MEMBRANE PROTEINS RESPONSIBLE FOR THE UPTAKE OF BOTH BILE ACIDS AND PHALLOIDIN", BIOCHIM. BIOPHYS. ACTA, vol. 773, 1984, pages 11 - 22, XP002059739
MIYATA ET AL.: "Functional monomers and polymers. 26. Synthesis and polymerization of vinyl cholate and vinyl dehydrocholate", MAKROMOL. CHEM., vol. 176, no. 7, 1975, pages 2139 - 2142, XP002059903
DATABASE WPI Section Ch Week 9507, Derwent World Patents Index; Class A96, AN 95-048757, XP002059742
WICHMAN A.: "Affinity Chromatography of Human Plasma Low- and High-Density Lipoproteins", BIOCHEM. J., vol. 181, no. 3, 1979, pages 691 - 698, XP002059740
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