Title:
POLYMER BRUSHES FOR IMMOBILIZING MOLECULES TO A SURFACE OR SUBSTRATE, WHERE THE POLYMERS HAVE WATER-SOLUBLE OR WATER-DISPERSIBLE SEGMENTS AND PROBES BONDED THERETO
Document Type and Number:
WIPO Patent Application WO2001002452
Kind Code:
A9
Abstract:
Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
Inventors:
KLAERNER GERRIT
NIELSEN RALPH B
MANSKY PAUL
BENOIT DIDIER
CHARMOT DOMINIQUE
JANDELEIT BERND
MAZZOLA LAURA T
NIELSEN RALPH B
MANSKY PAUL
BENOIT DIDIER
CHARMOT DOMINIQUE
JANDELEIT BERND
MAZZOLA LAURA T
Application Number:
PCT/US2000/018339
Publication Date:
July 25, 2002
Filing Date:
July 03, 2000
Export Citation:
Assignee:
SYMYX TECHNOLOGIES INC (US)
International Classes:
C08F4/00; C08F220/54; C08F220/58; G01N27/447; G01N33/543; (IPC1-7): C08F292/00; C08F220/58; C08F220/54; G01N33/48; C12Q1/68
Download PDF:
Previous Patent: POLY(METH)ACRYLIC PHOTOCHROMIC COATING
Next Patent: LOW-MOLECULAR OXYMETHYLENE POLYMER AND COMPOSITION THEREOF
Next Patent: LOW-MOLECULAR OXYMETHYLENE POLYMER AND COMPOSITION THEREOF