Title:
POLYMER BRUSHES FOR IMMOBILIZING MOLECULES TO A SURFACE
Document Type and Number:
WIPO Patent Application WO2002056021
Kind Code:
A3
Abstract:
Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
Inventors:
KLAERNER GERRIT (US)
BENOIT DIDIER (US)
CHARMOT DOMINIQUE (US)
NOMULA SRINIVAS (US)
PIOTTI MARCELO E (US)
MAZZOLA LAURA T (US)
BENOIT DIDIER (US)
CHARMOT DOMINIQUE (US)
NOMULA SRINIVAS (US)
PIOTTI MARCELO E (US)
MAZZOLA LAURA T (US)
Application Number:
PCT/US2002/000746
Publication Date:
September 18, 2003
Filing Date:
January 10, 2002
Export Citation:
Assignee:
SYMYX TECHNOLOGIES INC (US)
KLAERNER GERRIT (US)
BENOIT DIDIER (US)
CHARMOT DOMINIQUE (US)
NOMULA SRINIVAS (US)
PIOTTI MARCELO E (US)
MAZZOLA LAURA T (US)
KLAERNER GERRIT (US)
BENOIT DIDIER (US)
CHARMOT DOMINIQUE (US)
NOMULA SRINIVAS (US)
PIOTTI MARCELO E (US)
MAZZOLA LAURA T (US)
International Classes:
C08F293/00; G01N33/543; (IPC1-7): G01N33/543; C08F220/00; C08F293/00; C08J7/16; G01N33/545
Domestic Patent References:
| WO2000043539A2 | 2000-07-27 | |||
| WO2001002452A1 | 2001-01-11 | |||
| WO2000065352A1 | 2000-11-02 | |||
| WO1996000251A1 | 1996-01-04 |
Foreign References:
| EP1035218A1 | 2000-09-13 | |||
| EP1095711A2 | 2001-05-02 |
Other References:
INGALL, MICHAEL D. K. ET AL: "Surface Functionalization with Polymer and Block Copolymer Films Using Organometallic Initiators", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000), 122(32), 7845-7846, 2000, XP002238225
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