Title:
POLYMER COMPOUND FOR NUCLEIC ACID DELIVERY
Document Type and Number:
WIPO Patent Application WO/2019/151478
Kind Code:
A1
Abstract:
[Problem] To provide a polymer for nucleic acid delivery. [Solution] A polymer compound selected from a homopolymer of (a) and a block copolymer of (b). (a) A homopolymer comprising a polyglycidyl chain having a side chain including a primary amine. (b) A block copolymer of a polyglycidyl chain having a side chain including a primary amino acid, and a polyethylene glycol chain.
Inventors:
CABRAL HORACIO (JP)
UCHIDA SATOSHI (JP)
MIYAZAKI TAKUYA (JP)
UCHIDA SATOSHI (JP)
MIYAZAKI TAKUYA (JP)
Application Number:
PCT/JP2019/003617
Publication Date:
August 08, 2019
Filing Date:
February 01, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C08G65/28; A61K31/7088; A61K47/34; C08G65/328
Domestic Patent References:
| WO2012005376A1 | 2012-01-12 |
Foreign References:
| US20170218219A1 | 2017-08-03 | |||
| CN103936973A | 2014-07-23 | |||
| JP2009149728A | 2009-07-09 |
Other References:
O'CONNOR, AOIFE ET AL.: "Poly(Ethylene Glycol)- Based Backbones with High Peptide Loading Capacities", MOLECULES, vol. 19, no. 11, 30 October 2014 (2014-10-30), pages 17559 - 17577, XP055630501
MEYER, JOERG ET AL.: "Poly(glycidyl amine) and Copolymers with Glycidol and Glycidyl Amine Repeating Units: Synthesis and Characterization", MACROMOLECULES, vol. 44, no. 11, 14 June 2011 (2011-06-14), pages 4082 - 4091, XP055630503
U. SAHIN, NAT. REV. DRUG DISCOVERY, vol. 13, 2014, pages 759 - 780
N. B. TSUI, CLIN. CHEM., vol. 48, 2002, pages 1647 - 1653
S. UCHIDA, BIOMATERIALS, vol. 82, 2016, pages 221 - 228
K. HAYASHI, MACROMOL. RAPID COMMUN., vol. 37, 2016, pages 486 - 493
See also references of EP 3747928A4
MEYER, JOERG ET AL.: "Poly(glycidyl amine) and Copolymers with Glycidol and Glycidyl Amine Repeating Units: Synthesis and Characterization", MACROMOLECULES, vol. 44, no. 11, 14 June 2011 (2011-06-14), pages 4082 - 4091, XP055630503
U. SAHIN, NAT. REV. DRUG DISCOVERY, vol. 13, 2014, pages 759 - 780
N. B. TSUI, CLIN. CHEM., vol. 48, 2002, pages 1647 - 1653
S. UCHIDA, BIOMATERIALS, vol. 82, 2016, pages 221 - 228
K. HAYASHI, MACROMOL. RAPID COMMUN., vol. 37, 2016, pages 486 - 493
See also references of EP 3747928A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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