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Title:
POLYMER CONJUGATE OF HEXA-COORDINATED PLATINUM COMPLEX
Document Type and Number:
WIPO Patent Application WO/2017/047497
Kind Code:
A1
Abstract:
A drug delivery system (DDS) preparation of a platinum complex which selectively releases a highly active platinum complex in cells in reductive conditions, and exhibits the required high antitumour activity as a drug is yet to be obtained, and thus a novel DDS preparation of a platinum complex which can be used clinically is in demand. Accordingly, a polymer conjugate of a hexa-coordinated platinum complex is provided in which the hexa-coordinated platinum complex, which has halogens and hydroxyl groups at axial positions, is bonded directly or via spacers to side-chain carboxyl groups of a block copolymer having a polyethylene glycol structure moiety and a polyaspartic acid moiety or a polyglutamic acid moiety.

Inventors:
NAKAMURA MASAHARU (JP)
FUKUDA TSUYOSHI (JP)
KIKUCHI YUSAKU (JP)
WATANABE CHIHIRO (JP)
Application Number:
PCT/JP2016/076482
Publication Date:
March 23, 2017
Filing Date:
September 08, 2016
Export Citation:
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Assignee:
NIPPON KAYAKU KK (JP)
International Classes:
A61K33/243; C08G69/48; A61P35/00; C07F15/00; C08G65/333; C08G65/337; C08G69/10; C08G69/40
Domestic Patent References:
WO2005056641A12005-06-23
Foreign References:
JP2011105792A2011-06-02
JPH05117385A1993-05-14
JPS62207283A1987-09-11
JPS617283A1986-01-13
JPH03279392A1991-12-10
Other References:
See also references of EP 3351580A4
Attorney, Agent or Firm:
KAWAGUTI & PARTNERS (JP)
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