Title:
POLYMER CONJUGATE OF HEXA-COORDINATED PLATINUM COMPLEX
Document Type and Number:
WIPO Patent Application WO/2017/047497
Kind Code:
A1
Abstract:
A drug delivery system (DDS) preparation of a platinum complex which selectively releases a highly active platinum complex in cells in reductive conditions, and exhibits the required high antitumour activity as a drug is yet to be obtained, and thus a novel DDS preparation of a platinum complex which can be used clinically is in demand. Accordingly, a polymer conjugate of a hexa-coordinated platinum complex is provided in which the hexa-coordinated platinum complex, which has halogens and hydroxyl groups at axial positions, is bonded directly or via spacers to side-chain carboxyl groups of a block copolymer having a polyethylene glycol structure moiety and a polyaspartic acid moiety or a polyglutamic acid moiety.
Inventors:
NAKAMURA MASAHARU (JP)
FUKUDA TSUYOSHI (JP)
KIKUCHI YUSAKU (JP)
WATANABE CHIHIRO (JP)
FUKUDA TSUYOSHI (JP)
KIKUCHI YUSAKU (JP)
WATANABE CHIHIRO (JP)
Application Number:
PCT/JP2016/076482
Publication Date:
March 23, 2017
Filing Date:
September 08, 2016
Export Citation:
Assignee:
NIPPON KAYAKU KK (JP)
International Classes:
A61K33/243; C08G69/48; A61P35/00; C07F15/00; C08G65/333; C08G65/337; C08G69/10; C08G69/40
Domestic Patent References:
WO2005056641A1 | 2005-06-23 |
Foreign References:
JP2011105792A | 2011-06-02 | |||
JPH05117385A | 1993-05-14 | |||
JPS62207283A | 1987-09-11 | |||
JPS617283A | 1986-01-13 | |||
JPH03279392A | 1991-12-10 |
Other References:
See also references of EP 3351580A4
Attorney, Agent or Firm:
KAWAGUTI & PARTNERS (JP)
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