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Title:
POLYMER CONJUGATE OF PODOPHYLLOTOXIN
Document Type and Number:
WIPO Patent Application WO/2007/135910
Kind Code:
A1
Abstract:
A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded. A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxylic acid group of polyethyleneglycol/ polyaspartic acid copolymer and a hydroxyl group of podophyllotoxin are linked via an ester bond is provided.

Inventors:
KITAGAWA, Masayuki (31-12 Shimo 3-chome, Kita-k, Tokyo 88, 1158588, JP)
北川 正行 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
ISHIKAWA, Keizou (31-12 Shimo 3-chome, Kita-k, Tokyo 88, 1158588, JP)
石川 恵三 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
YAMAMOTO, Keiichirou (31-12 Shimo 3-chome, Kita-k, Tokyo 88, 1158588, JP)
Application Number:
JP2007/060026
Publication Date:
November 29, 2007
Filing Date:
May 16, 2007
Export Citation:
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Assignee:
NIPPON KAYAKU KABUSHIKI KAISHA (11-2, Fujimi 1-chome Chiyoda-k, Tokyo 72, 1028172, JP)
日本化薬株式会社 (〒72 東京都千代田区富士見一丁目11番2号 Tokyo, 1028172, JP)
KITAGAWA, Masayuki (31-12 Shimo 3-chome, Kita-k, Tokyo 88, 1158588, JP)
北川 正行 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
ISHIKAWA, Keizou (31-12 Shimo 3-chome, Kita-k, Tokyo 88, 1158588, JP)
石川 恵三 (〒88 東京都北区志茂3-31-12 日本化薬株式会社 医薬研究所内 Tokyo, 1158588, JP)
International Classes:
C08G81/00; A61K31/365; A61K31/7048; A61K47/34; A61K47/48; A61P35/00; C08G85/00
Domestic Patent References:
WO2004039869A12004-05-13
Foreign References:
JPS6296088A1987-05-02
JPS62145093A1987-06-29
JPS6310789A1988-01-18
JPS6323884A1988-02-01
JPS6461422A1989-03-08
JPS6461423A1989-03-08
JPH10513187A1998-12-15
JP2003509385A2003-03-11
JP2003511349A2003-03-25
JP2003525238A2003-08-26
JP2694923B21997-12-24
JP3268913B22002-03-25
JPH10513187A1998-12-15
JP2694923B21997-12-24
JP3268913B22002-03-25
Other References:
See also references of EP 2019122A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshio et al. (Kawaguti & Partners, Jochi Kioizaka Bldg. 7-1, Kioi-cho, Chiyoda-k, Tokyo 94, 1020094, JP)
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