POLYMER CONJUGATE OF SULFOXIDE DERIVATIVE-COORDINATED PLATINUM(II) COMPLEX

WIPO Patent Application WO/2017/110669

A1

[Problem] A DDS preparation of a platinum complex showing the high antitumor effect and reduced side effects required as a medicine, that is, a clinically useable DDS preparation of a platinum complex characterized by being conjugated to a polymer carrier different from conventional ones, is desired. [Solution] Provided is a polymer conjugate of a platinum(II) complex, in which the sulfoxide group of a sulfoxide derivative introduced into a side chain carboxy group in a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety is coordinated to the platinum.

WO/2006/043992	POLYBENZIMIDAZOLE COMPOUNDS, POLYMERIC MEDIA, AND METHODS OF POST-POLYMERIZATION MODIFICATIONS
JPH0725882	INDUSTRIAL APPLICABILITY: Unsaturated group-containing aromatic polyamide oligomer and method for producing the same.
WO/2019/238090	STRONG BASE-INITIATED N-CARBOXYANHYDRIDE RAPID RING-OPENING POLYMERISATION METHOD

NAKAMURA MASAHARU (JP)
FUKUDA TSUYOSHI (JP)
YAMAKAWA KEN (JP)
KATO TAKUYA (JP)

PCT/JP2016/087521

June 29, 2017

December 16, 2016

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NIPPON KAYAKU KK (JP)

C08G69/48; A61K31/282; A61K31/555; A61K47/50; A61P35/00; C08G65/334; C08G69/08; C08G81/00

WO2005056641A1	2005-06-23
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WO1989009598A1	1989-10-19

JP2011105792A	2011-06-02
JPH05117385A	1993-05-14
JPH09504275A	1997-04-28
CN103450281A	2013-12-18
US6350740B1	2002-02-26
GB2304712A	1997-03-26
JPH05500218A	1993-01-21
JP2006512462A	2006-04-13
JP3268913B2	2002-03-25
JPH0769900A	1995-03-14
JP2011173908A	2011-09-08

See also references of EP 3395857A4

KAWAGUTI & PARTNERS (JP)

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