Title:
POLYMER CONJUGATES OF HEDGEHOG PROTEINS AND USES
Document Type and Number:
WIPO Patent Application WO2000073337
Kind Code:
A9
Abstract:
A hedgehog polypeptide comprising hedgehog coupled to a polymer containing a polyalkylene glycol moiety wherein the hedgehog and the polyalkylene glycol moiety are arranged such that the hedgehog has an enhanced bioavailability relative to another hedgehog lacking the polymer and exhibits no decrease in activity as compared to non-conjugated hedgehog. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
Inventors:
PEPINSKY R BLAKE (US)
TAYLOR FREDERICK (US)
GARBER ELLEN (US)
TAYLOR FREDERICK (US)
GARBER ELLEN (US)
Application Number:
PCT/US2000/014741
Publication Date:
February 14, 2002
Filing Date:
May 26, 2000
Export Citation:
Assignee:
BIOGEN INC (US)
PEPINSKY R BLAKE (US)
TAYLOR FREDERICK (US)
GARBER ELLEN (US)
PEPINSKY R BLAKE (US)
TAYLOR FREDERICK (US)
GARBER ELLEN (US)
International Classes:
A61K38/00; A61K47/48; A61P25/00; C12N15/09; A61P25/16; A61P25/28; C07K14/46; C07K14/47; C07K16/18; C07K17/08; C07K19/00; (IPC1-7): C07K14/46; A61K47/48; A61K38/17
Download PDF:
Previous Patent: FIMBRIAL PROTEINS
Next Patent: COMPOSITIONS AND METHODS FOR THE THERAPY, DIAGNOSIS AND MONITORING OF BREAST CANCER
Next Patent: COMPOSITIONS AND METHODS FOR THE THERAPY, DIAGNOSIS AND MONITORING OF BREAST CANCER