Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
A POLYMER NETWORK, METHOD FOR PRODUCTION, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/020516
Kind Code:
A3
Abstract:
A polymer network, method for production, and uses thereof The present disclosure relates to a polymer network comprising a compound of Formula I cross-linked to a compound selected from the group consisting of a compound of Formula II; hyaluronate aldehyde, alginate aldehyde, dextran aldehyde, starch aldehyde, and chitosan aldehyde. It also relates to a process of preparing the polymer network. The present disclosure further relates to compositions comprising the polymer network and methods of preventing conditions and diseases that are caused by micro-organism. The present disclosure still further relates to a biocompatible antimicrobial hydrogel, a process for preparing the hydrogel, and methods of using the same, including a variety of tissue-related applications in which rapid adhesion to the tissue and gel formation is desired, as well as local delivery of pharmaceutical drugs to a site of application.

Inventors:
HALDAR, Jayanta (Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 4, 560064, IN)
HOQUE, Jiaul (Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 4, 560064, IN)
Application Number:
IN2017/050311
Publication Date:
February 01, 2018
Filing Date:
July 28, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 4, 560064, IN)
International Classes:
C08B31/00; C08B37/00; C08B37/02; C08B37/08
Domestic Patent References:
WO2009028965A12009-03-05
Foreign References:
EP3081236A12016-10-19
Other References:
JIAUL HOQUE ET AL: "Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties", MOLECULAR PHARMACEUTICS, vol. 14, no. 4, 3 April 2017 (2017-04-03), US, pages 1218 - 1230, XP055424997, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.6b01104
MOHAN NEETHU ET AL: "Chitosan-hyaluronic acid hydrogel for cartilage repair", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ELSEVIER BV, NL, vol. 104, 27 March 2017 (2017-03-27), pages 1936 - 1945, XP085173005, ISSN: 0141-8130, DOI: 10.1016/J.IJBIOMAC.2017.03.142
LI LING ET AL: "Biodegradable and injectablein situcross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention", BIOMATERIALS, vol. 35, no. 12, 4 February 2014 (2014-02-04), pages 3903 - 3917, XP028611248, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2014.01.050
CABRAL JAYDEE D ET AL: "Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, SPRINGER NEW YORK LLC, UNITED STATES, vol. 25, no. 12, 2 August 2014 (2014-08-02), pages 2743 - 2756, XP035377099, ISSN: 0957-4530, [retrieved on 20140802], DOI: 10.1007/S10856-014-5292-3
FAN L ET AL: "Preparation and properties of alginate/carboxymethyl chitosan blend fibers", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 65, no. 4, 13 September 2006 (2006-09-13), pages 447 - 452, XP027941585, ISSN: 0144-8617, [retrieved on 20060913]
NG VICTOR W L ET AL: "Antimicrobial hydrogels: A new weapon in the arsenal against multidrug-resistant infections", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 78, 1 November 2014 (2014-11-01), pages 46 - 62, XP029104083, ISSN: 0169-409X, DOI: 10.1016/J.ADDR.2014.10.028
BOUTEN PETRA J M ET AL: "The chemistry of tissue adhesive materials", PROGRESS IN POLYMER SCIENCE, vol. 39, no. 7, 18 February 2014 (2014-02-18), pages 1375 - 1405, XP028865324, ISSN: 0079-6700, DOI: 10.1016/J.PROGPOLYMSCI.2014.02.001
MANAL A. AZIZ ET AL: "Antimicrobial Properties of a Chitosan Dextran-Based Hydrogel forSurgical Use", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 56, no. 1, 1 January 2012 (2012-01-01), pages 280 - 287, XP055455859, ISSN: 0066-4804, DOI: 10.1128/AAC.05463-11
MAGGIE CHAN ET AL: "Reducing the Oxidation Level of Dextran Aldehyde in a Chitosan/Dextran-Based Surgical Hydrogel Increases Biocompatibility and Decreases Antimicrobial Efficacy", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 12, 16 June 2015 (2015-06-16), pages 13798 - 13814, XP055455864, DOI: 10.3390/ijms160613798
ANA SALOMÉ VEIGA ET AL: "Antimicrobial hydrogels for the treatment of infection : Antimicrobial Hydrogels for the Treatment of Infection", BIOPOLYMERS, vol. 100, no. 6, 1 November 2013 (2013-11-01), US, pages 637 - 644, XP055455868, ISSN: 0006-3525, DOI: 10.1002/bip.22412
JUAN LI ET AL: "pH and glucose dually responsive injectable hydrogel prepared by in situ crosslinking of phenylboronic modified chitosan and oxidized dextran", JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, vol. 53, no. 10, 15 May 2015 (2015-05-15), pages 1235 - 1244, XP055455932, ISSN: 0887-624X, DOI: 10.1002/pola.27556
Attorney, Agent or Firm:
LAKSHMIKUMARAN, Malathi et al. (B6/10, Safdarjung Enclave, New Delhi 9, 110029, IN)
Download PDF: