Title:
POLYMER VESICLE LOADED WITH ONCOLYTIC PEPTIDE AND COMBINED MEDICATION OF SAME WITH VESICLE IMMUNE ADJUVANT AND PD-1 MONOCLONAL ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2022/253344
Kind Code:
A1
Abstract:
A polymer vesicle loaded with oncolytic peptide, combined medication of same with immune adjuvant and antibodies, and application thereof. A polymer solution is mixed with an oncolytic peptide solution, and then dialysed to obtain a polymer vesicle loaded with the oncolytic peptide; the polymer solution is mixed with an immune adjuvant solution, and then dialysed to obtain a polymer vesicle loaded with the immune adjuvant. The administration method of the combined drug system can effectively target tumour sites and reshape the tumor microenvironment to thereby achieve a potent and long-term immune memory; the use window of oncolytic peptides and CpG ODNS is broadened, providing a new treatment solution for tumours that cannot be injected intratumorally or metastatically infiltrated tumours.
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Inventors:
MENG FENGHUA (CN)
XIA YIFENG (CN)
ZHONG ZHIYUAN (CN)
XIA YIFENG (CN)
ZHONG ZHIYUAN (CN)
Application Number:
PCT/CN2022/097031
Publication Date:
December 08, 2022
Filing Date:
June 03, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K9/127; A61K38/40; A61K39/39; A61K39/395; A61K47/34; A61P35/00
Foreign References:
| CN113368053A | 2021-09-10 | |||
| CN110229323A | 2019-09-13 | |||
| CN111437258A | 2020-07-24 | |||
| CN107096038A | 2017-08-29 | |||
| CN112076159A | 2020-12-15 | |||
| US20150250837A1 | 2015-09-10 |
Other References:
ZHOU CHENG; XIA YIFENG; WEI YAOHUA; CHENG LIANG; WEI JINGJING; GUO BEIBEI; MENG FENGHUA; CAO SHOUPENG; VAN HEST JAN C.M.; ZHONG ZH: "GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma", ACTA BIOMATERIALIA, vol. 113, 18 June 2020 (2020-06-18), AMSTERDAM, NL, pages 512 - 521, XP086239091, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2020.06.020
HAUG BENGT ERIK, CAMILIO KETIL ANDRÉ, ELIASSEN LIV TONE, STENSEN WENCHE, SVENDSEN JOHN SIGURD, BERG KRISTEL, MORTENSEN BJARTE, SER: "Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 7, 14 April 2016 (2016-04-14), US , pages 2918 - 2927, XP093012004, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b02025
ZHANG, NA : "Research Progress in Immunotherapy for Melanoma", JOURNAL OF PRACTICAL ONCOLOGY, vol. 29, no. 1, 31 December 2014 (2014-12-31), CN , pages 11 - 17, XP009541654, ISSN: 1001-1692, DOI: 10.13267/j.cnki.syzlzz.2014.01.003
HAUG BENGT ERIK, CAMILIO KETIL ANDRÉ, ELIASSEN LIV TONE, STENSEN WENCHE, SVENDSEN JOHN SIGURD, BERG KRISTEL, MORTENSEN BJARTE, SER: "Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 7, 14 April 2016 (2016-04-14), US , pages 2918 - 2927, XP093012004, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b02025
ZHANG, NA : "Research Progress in Immunotherapy for Melanoma", JOURNAL OF PRACTICAL ONCOLOGY, vol. 29, no. 1, 31 December 2014 (2014-12-31), CN , pages 11 - 17, XP009541654, ISSN: 1001-1692, DOI: 10.13267/j.cnki.syzlzz.2014.01.003
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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