Title:
POLYMERIC BILE ACID DERIVATIVES INHIBIT HEPATITIS B AND D VIRUS AND NTCP TRANSPORT
Document Type and Number:
WIPO Patent Application WO/2016/045642
Kind Code:
A1
Abstract:
The invention provides for treating HBV or HDV infection or inhibiting human sodium taurocholate co-transporting polypeptide (hNTCP) with a polymeric bile acid or salt thereof, and pharmaceutical compositions comprising a polymeric bile acid or salt thereof, and a second HBV or HDV medicament.
Inventors:
LI WENHUI (CN)
QI XIANGBING (CN)
YAN HUAN (CN)
LIU YANG (CN)
WANG ZHIQIANG (CN)
PENG BO (CN)
ZHANG LEI (CN)
QI XIANGBING (CN)
YAN HUAN (CN)
LIU YANG (CN)
WANG ZHIQIANG (CN)
PENG BO (CN)
ZHANG LEI (CN)
Application Number:
PCT/CN2015/091000
Publication Date:
March 31, 2016
Filing Date:
September 28, 2015
Export Citation:
Assignee:
NAT INST OF BIOLOG SCIENCES BEIJING (CN)
International Classes:
A61K31/575; A61P31/20; C07J9/00
Domestic Patent References:
| WO2013159243A1 | 2013-10-31 |
Foreign References:
| CN101182331A | 2008-05-21 | |||
| CN101439187A | 2009-05-27 |
Other References:
KOICHI WATASHI ET AL.: "NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 15, 19 February 2014 (2014-02-19), pages 2892 - 2905, XP009183107, ISSN: 1422-0067
YAN ET AL., ELIFE, vol. 1, 2012, pages e00049
YAN ET AL., J VIROL, vol. 87, 2013, pages 7977 - 7991
YAN ET AL., J VIROL, vol. 88, 2014, pages 3273 - 3284
BLANCHET ET AL., ANTIVIRAL RESEARCH, vol. 106, 2014, pages 111 - 115
INT. J. MOL. SCI., vol. 15, no. 2, 19 February 2014 (2014-02-19), pages 2892 - 2905
WERMUTH, C. G.: "The Practice of Medicinal Chemistry", 1996, ACADEMIC PRESS, pages: 203
"Remington's Pharmaceutical Science", 1991, MACK PUBLISHING CO
YAN ET AL., J VIROL, MAR, vol. 88, no. 6, 2014, pages 3273 - 3284
NI ET AL., GASTROENTEROL, vol. 146, no. 4, April 2014 (2014-04-01), pages 902 - 905
KONIG ET AL., J HEPATOL, 15 May 2014 (2014-05-15)
"GenBank", Database accession no. EU554535.1
See also references of EP 3197459A4
YAN ET AL., ELIFE, vol. 1, 2012, pages e00049
YAN ET AL., J VIROL, vol. 87, 2013, pages 7977 - 7991
YAN ET AL., J VIROL, vol. 88, 2014, pages 3273 - 3284
BLANCHET ET AL., ANTIVIRAL RESEARCH, vol. 106, 2014, pages 111 - 115
INT. J. MOL. SCI., vol. 15, no. 2, 19 February 2014 (2014-02-19), pages 2892 - 2905
WERMUTH, C. G.: "The Practice of Medicinal Chemistry", 1996, ACADEMIC PRESS, pages: 203
"Remington's Pharmaceutical Science", 1991, MACK PUBLISHING CO
YAN ET AL., J VIROL, MAR, vol. 88, no. 6, 2014, pages 3273 - 3284
NI ET AL., GASTROENTEROL, vol. 146, no. 4, April 2014 (2014-04-01), pages 902 - 905
KONIG ET AL., J HEPATOL, 15 May 2014 (2014-05-15)
"GenBank", Database accession no. EU554535.1
See also references of EP 3197459A4
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