Title:
POLYMERIC MATRICES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO1995006077
Kind Code:
A3
Abstract:
This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF á, e.g., certain autoimmune and inflammatory conditions, as well as septic shock.
Inventors:
ACEMOGLU MURAT (CH)
BANTLE SIEGFRIED (CH)
BODMER DAVID (CH)
CAMMISULI SALVATORE (CH)
HIESTAND PETER (CH)
NIMMERFALL FRITZ (CH)
STOLL GEORG (CH)
BANTLE SIEGFRIED (CH)
BODMER DAVID (CH)
CAMMISULI SALVATORE (CH)
HIESTAND PETER (CH)
NIMMERFALL FRITZ (CH)
STOLL GEORG (CH)
Application Number:
PCT/EP1994/002833
Publication Date:
May 04, 1995
Filing Date:
August 26, 1994
Export Citation:
Assignee:
SANDOZ LTD (CH)
SANDOZ AG (CH)
ACEMOGLU MURAT (CH)
BANTLE SIEGFRIED (CH)
BODMER DAVID (CH)
CAMMISULI SALVATORE (CH)
HIESTAND PETER (CH)
NIMMERFALL FRITZ (CH)
STOLL GEORG (CH)
SANDOZ AG (CH)
ACEMOGLU MURAT (CH)
BANTLE SIEGFRIED (CH)
BODMER DAVID (CH)
CAMMISULI SALVATORE (CH)
HIESTAND PETER (CH)
NIMMERFALL FRITZ (CH)
STOLL GEORG (CH)
International Classes:
A61K9/14; A61K9/16; A61K9/20; A61K9/50; A61K38/00; A61K38/16; A61K9/00; A61K38/20; A61K38/31; A61K45/00; A61K47/26; A61K47/34; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P37/02; C08G64/00; C08G64/02; C08G64/18; C08G64/20; C08G64/34; C08L101/16; (IPC1-7): C08G64/02; C08G64/34; C08G64/18; A61K38/20; A61K9/16; A61K9/20
Domestic Patent References:
| WO1993011793A1 | 1993-06-24 |
Foreign References:
| US3953383A | 1976-04-27 | |||
| US3585168A | 1971-06-15 | |||
| US4379138A | 1983-04-05 | |||
| US4999417A | 1991-03-12 | |||
| EP0535937A1 | 1993-04-07 |
Other References:
DATABASE WPI Week 9206, Derwent World Patents Index; AN 92-045972
TAKEO KAWAGUCHI ET AL: "Examination of biodegradability of poly(ethylene carbonate) and poly(propylene carbonate) in the peritoneal cavity in rats", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 31, no. 4, 1983, TOKYO JP, pages 1400 - 1403
TAKEO KAWAGUCHI ET AL: "Examination of biodegradability of poly(ethylene carbonate) and poly(propylene carbonate) in the peritoneal cavity in rats", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 31, no. 4, 1983, TOKYO JP, pages 1400 - 1403
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