Title:
POLYMERIZABLE COMPOUND, COMPOUND, AND METHOD FOR PRODUCING BORANOPHOSPHATE OLIGOMER
Document Type and Number:
WIPO Patent Application WO/2018/088491
Kind Code:
A1
Abstract:
Provided is a polymerizable compound represented by formula A-1 and A-2. In formula A-1 or A-2: R1 represents an electron donor group; n represents an integer of 1 to 5; R2 represents a hydrogen atom, a halogen atom, or -ORO; RO represents a hydrogen atom, an alkyl group, or a hydroxyl group protecting group; R3 represents a hydrogen atom or a hydroxyl group protecting group; and X represents a structure represented by any of formulas B-1 through B-5.
Inventors:
WADA TAKESHI (JP)
SAITO TATSUYA (JP)
ISHII YUKA (JP)
NUKAGA YOHEI (JP)
SAITO TATSUYA (JP)
ISHII YUKA (JP)
NUKAGA YOHEI (JP)
Application Number:
PCT/JP2017/040469
Publication Date:
May 17, 2018
Filing Date:
November 09, 2017
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
C07F9/6584; C07F5/02; C07F9/6558
Foreign References:
| JP2012510460A | 2012-05-10 |
Other References:
IWAMOTO, N. ET AL.: "Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates by an oxazaphospholidine approach using acid-labile-protecting groups", TETRAHEDRON LETTERS, vol. 53, no. 33, 2012, pages 4361 - 4364, XP028427772
NUKAGA, Y. ET AL.: "Enhancement of the affinity of 2′-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone", RSC ADVANCES, vol. 5, no. 4, 2015, pages 2392 - 2395, XP055501543
SAITO, TATSUYA ET AL.: "4C2-10 Stereocontrolled synthesis of boranophosphate DNA by and oxazaphospholidine approach", THE 97TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN, vol. 97, 3 March 2017 (2017-03-03), pages 4C2 - 10, XP009515055
J. AM. CHEM. SOC., vol. 112, 1990, pages 9000
TETRAHEDRON LETT., vol. 38, 1997, pages 4957
J. AM. CHEM. SOC., vol. 120, 1998, pages 9417
TETRAHEDRON LETT., vol. 39, 1998, pages 3899
T. ANGEW. CHEM. INT. ED., vol. 48, 2009, pages 496 - 499
T. RSC ADV., vol. 5, 2015, pages 2392 - 2395
TETRAHEDRON LETT., vol. 53, 2012, pages 4361 - 4364
RSC ADV., vol. 5, 2015, pages 2392 - 2395
GREEN ET AL.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
See also references of EP 3539970A4
NUKAGA, Y. ET AL.: "Enhancement of the affinity of 2′-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone", RSC ADVANCES, vol. 5, no. 4, 2015, pages 2392 - 2395, XP055501543
SAITO, TATSUYA ET AL.: "4C2-10 Stereocontrolled synthesis of boranophosphate DNA by and oxazaphospholidine approach", THE 97TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN, vol. 97, 3 March 2017 (2017-03-03), pages 4C2 - 10, XP009515055
J. AM. CHEM. SOC., vol. 112, 1990, pages 9000
TETRAHEDRON LETT., vol. 38, 1997, pages 4957
J. AM. CHEM. SOC., vol. 120, 1998, pages 9417
TETRAHEDRON LETT., vol. 39, 1998, pages 3899
T. ANGEW. CHEM. INT. ED., vol. 48, 2009, pages 496 - 499
T. RSC ADV., vol. 5, 2015, pages 2392 - 2395
TETRAHEDRON LETT., vol. 53, 2012, pages 4361 - 4364
RSC ADV., vol. 5, 2015, pages 2392 - 2395
GREEN ET AL.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
See also references of EP 3539970A4
Attorney, Agent or Firm:
NAKAJIMA, Jun et al. (JP)
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