Title:
POLYMERS CONTAINING BETA-AMINO-ESTER (BAE) AND BETA-THIO-ESTER (BTE)
Document Type and Number:
WIPO Patent Application WO/2023/108111
Kind Code:
A3
Abstract:
Provided herein are branched BAE/BTE -containing polymers useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The polymers form stable compositions and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
Inventors:
FINN M G (US)
SANTANGELO PHILIP (US)
VANOVER DARYLL (US)
ROTOLO LAURA (US)
BRUNO NICHOLAS (US)
SANTANGELO PHILIP (US)
VANOVER DARYLL (US)
ROTOLO LAURA (US)
BRUNO NICHOLAS (US)
Application Number:
PCT/US2022/081249
Publication Date:
August 10, 2023
Filing Date:
December 09, 2022
Export Citation:
Assignee:
GEORGIA TECH RES INST (US)
International Classes:
A61K47/34; A61K47/69; C08G63/685; C08G73/02; C08L79/02
Domestic Patent References:
| WO2008011561A2 | 2008-01-24 | |||
| WO2020243647A1 | 2020-12-03 |
Foreign References:
| US20150273071A1 | 2015-10-01 |
Other References:
YANG WEI, PAN CAI-YUAN: "A feasible synthetic strategy for three-armed star poly(ester amine) via Michael addition polymerization", E-POLYMERS, WALTER DE GRUYTER GMBH, DE, vol. 9, no. 1, 1 December 2009 (2009-12-01), DE , XP093086711, ISSN: 2197-4586, DOI: 10.1515/epoly.2009.9.1.236
NAGA NAOFUMI, SATO MITSUSUKE, MORI KENSUKE, NAGEH HASSAN, NAKANO TAMAKI: "Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds", POLYMERS, vol. 12, no. 9, pages 1 - 17, XP093086712, DOI: 10.3390/polym12092047
NAGA NAOFUMI, SATO MITSUSUKE, MORI KENSUKE, NAGEH HASSAN, NAKANO TAMAKI: "Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds", POLYMERS, vol. 12, no. 9, pages 1 - 17, XP093086712, DOI: 10.3390/polym12092047
Attorney, Agent or Firm:
HOFFMAN, David, B. (US)
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