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Patent Searching and Data


Title:
POLYMORPH OF NUCLEOSIDE PHOSPHORAMIDATE PRODRUG AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/019188
Kind Code:
A1
Abstract:
Provided are a crystal form A of a nucleoside phosphoramidate prodrug as shown in formula I and a preparation method therefor. The crystal form A at least has an X-ray powder diffraction (XRPD) pattern with peaks at the 2θ angles of 6.9 ± 0.2°, 13.9 ± 0.2°, 20.8 ± 0.2° and 21.1 ± 0.2°. The crystal form A is stable in nature and suitable for being prepared into various dosage forms. The preparation method is simple in operation, and the prepared crystal form A is high in purity and low in industrialization costs.

Inventors:
YUAN JIANDONG (CN)
GU JIANING (CN)
HUANG YANGQING (CN)
MIAO LINFENG (CN)
LIANG CHAOHUA (CN)
SUN ZHANLI (CN)
Application Number:
CN2017/093925
Publication Date:
February 01, 2018
Filing Date:
July 21, 2017
Export Citation:
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Assignee:
BRIGHTGENE BIO-MEDICAL TECH CO LTD (CN)
International Classes:
C07H19/10; A61K31/7068; A61P35/00; C07H1/06
Domestic Patent References:
WO2016055769A12016-04-14
WO2015198058A12015-12-30
WO2014076490A12014-05-22
Foreign References:
CN106539810A2017-03-29
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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