Title:
POLYMORPHIC FORMS OF COMPOUND AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/194252
Kind Code:
A1
Abstract:
Disclosed in the present invention are polymorphic forms of a compound and a preparation method therefor and an application thereof. A crystal form III of a compound A uses Cu-Kα radiation, and X-ray powder diffraction expressed at 2θ angles has characteristic peaks at 12.15±0.20°, 15.98±0.20°, 16.62±0.20°, 17.14±0.20°, 24.32±0.20°, and 26.08±0.20°. A crystal form VII of the compound A uses Cu-Kα radiation, and X-ray powder diffraction expressed at 2θ angles has characteristic peaks at 12.94±0.20°, 14.41±0.20°, 15.64±0.20°, 17.25±0.20°, 21.75±0.20°, and 24.23±0.20°. The polymorphic forms prepared by the present invention are good in stability, and can be stably stored under the conditions of high temperature and low relative humidity.
Inventors:
YE GUOZHONG (CN)
TIAN YONG (CN)
SUN ZONGGUO (CN)
LUAN LINBO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
TIAN YONG (CN)
SUN ZONGGUO (CN)
LUAN LINBO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2022/081514
Publication Date:
September 22, 2022
Filing Date:
March 17, 2022
Export Citation:
Assignee:
SHANGHAI MEIYUE BIOTECH DEV CO LTD (CN)
International Classes:
C07D401/12; A61K31/4439; A61P1/00; A61P3/00; A61P9/10; A61P11/06; A61P17/00; A61P19/02; A61P19/06; A61P29/00; A61P35/00; A61P37/06; A61P37/08
Domestic Patent References:
| WO2021057785A1 | 2021-04-01 | |||
| WO2020135513A1 | 2020-07-02 |
Foreign References:
| CN113831320A | 2021-12-24 | |||
| CN111560012A | 2020-08-21 | |||
| CN111499612A | 2020-08-07 | |||
| CN110835332A | 2020-02-25 | |||
| CN202110297078A | 2021-03-19 | |||
| CN2020117093W | 2020-09-23 | |||
| CN201910906833A | 2019-09-24 |
Other References:
FLANNERY ET AL., BIOCHEM. PHARMACOL., vol. 80, no. 12, 2010, pages 1981 - 1991
CHAUDHARY D ET AL., J. MED. CHEM., vol. 58, no. 1, 2015, pages 96 - 110
CHAUDHARY D ET AL., J. MED. CHEM., vol. 58, no. 1, 2015, pages 96 - 110
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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