Title:
POLYMORPHIC MODIFICATIONS OF 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID AND PROCESSES FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/1999/065885
Kind Code:
A1
Abstract:
A process for preparing various polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid each selectively by crystallization under the specific conditions determined by temperature and methanol/water ratio of the mixed solvent to be used; and polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid as obtained by this process. A process of subjecting a specific polymorphic modification of the above acid to heating and vacuum drying to thereby obtain another polymorphic modification of the acid or an amorphous modification thereof; and polymorphic or amorphous modifications of the acid as obtained by this process.
Inventors:
MATSUMOTO KOICHI (JP)
WATANABE KENZO (JP)
HIRAMATSU TOSHIYUKI (JP)
KITAMURA MITSUTAKA (JP)
WATANABE KENZO (JP)
HIRAMATSU TOSHIYUKI (JP)
KITAMURA MITSUTAKA (JP)
Application Number:
PCT/JP1999/003258
Publication Date:
December 23, 1999
Filing Date:
June 18, 1999
Export Citation:
Assignee:
TEIJIN LTD (JP)
MATSUMOTO KOICHI (JP)
WATANABE KENZO (JP)
HIRAMATSU TOSHIYUKI (JP)
KITAMURA MITSUTAKA (JP)
MATSUMOTO KOICHI (JP)
WATANABE KENZO (JP)
HIRAMATSU TOSHIYUKI (JP)
KITAMURA MITSUTAKA (JP)
International Classes:
C07D277/56; (IPC1-7): C07D277/56
Domestic Patent References:
| WO1992009279A1 | 1992-06-11 |
Foreign References:
| JPH06345724A | 1994-12-20 | |||
| JPH1045733A | 1998-02-17 |
Other References:
See also references of EP 1020454A4
Attorney, Agent or Firm:
Maeda, Sumihiro (Intellectual Property Center 1-1 Uchisaiwaicho
2-chome Chiyoda-ku, Tokyo, JP)
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