Title:
POLYNUCLEOTIDE DERIVED FROM NOVEL HEPATITIS C VIRUS STRAIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/024875
Kind Code:
A1
Abstract:
Disclosed is a polynucleotide that encodes a sequence 2 or a sequence 5 amino acid sequence, or an amino acid sequence having at least 98% identity to said amino acid sequence; preferably a polynucleotide that comprises a substitution of an amino acid equivalent to a glutamic acid at position 1202 in sequence 2 (position 177 in sequence 5) with a glycine, a substitution of an amino acid equivalent to a glutamic acid at position 1056 in sequence 2 (position 31 in sequence 5) with a valine, and a substitution of an amino acid equivalent to an alanine at position 2199 in sequence 2 (position 1174 in sequence 5) with a threonine.
Inventors:
KOHARA MICHINORI (JP)
ARAI MASAAKI (JP)
MUKAIDANI CHISE (JP)
ARAI MASAAKI (JP)
MUKAIDANI CHISE (JP)
Application Number:
PCT/JP2010/064417
Publication Date:
March 03, 2011
Filing Date:
August 25, 2010
Export Citation:
Assignee:
TOKYO METROPOLITAN ORG MED RES (JP)
MITSUBISHI TANABE PHARMA CORP (JP)
PHOENIXBIO CO LTD (JP)
KOHARA MICHINORI (JP)
ARAI MASAAKI (JP)
MUKAIDANI CHISE (JP)
MITSUBISHI TANABE PHARMA CORP (JP)
PHOENIXBIO CO LTD (JP)
KOHARA MICHINORI (JP)
ARAI MASAAKI (JP)
MUKAIDANI CHISE (JP)
International Classes:
C12N15/09; A01K67/027; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| WO2002028174A1 | 2002-04-11 | |||
| WO2003037081A1 | 2003-05-08 | |||
| WO2005028652A1 | 2005-03-31 |
Foreign References:
| JPH07503614A | 1995-04-20 | |||
| JP2001017187A | 2001-01-23 | |||
| JP2002171978A | 2002-06-18 |
Other References:
DATABASE GENBANK [online] 31 May 2009 (2009-05-31), TIMM, J. ET AL.: "Definition: Hepatitis C virus subtype la isolate L8168, complete genome", XP008150559, Database accession no. EU781759
DATABASE GENBANK [online] 31 May 2009 (2009-05-31), KUNTZEN, T. ET AL.: "Definition: Hepatitis C virus subtype la isolate 03P, complete genome", XP008150561, Database accession no. EU781810
DATABASE GENBANK [online] 2 January 2008 (2008-01-02), DONLIN, M.J. ET AL.: "Definition: Hepatitis C virus isolate 6025 polyprotein gene, complete cds", XP008150566, Database accession no. EF407427
DATABASE GENBANK [online] 2 January 2008 (2008-01-02), DONLIN, M.J. ET AL.: "Definition: Hepatitis C virus isolate 8003 polyprotein gene, complete cds", XP008150560, Database accession no. EF407439
DONLIN M.J. ET AL.: "Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy.", JOURNAL OF VIROLOGY, vol. 81, no. 15, 2007, pages 8211 - 8224, XP008150565
HEPATORIGY, vol. 10, 1994, pages 1321 - 1324
BIOCHEM. BIOPHIS. RES. COMMUN., vol. 183, 1992, pages 334 - 342
SCIENCE, vol. 285, 1999, pages 110 - 113
SCIENCE, vol. 290, 2000, pages 1972 - 1974
J. VIROL., vol. 76, 2002, pages 2997 - 3006
J. VIROL., vol. 77, 2003, pages 3181 - 3190
TATENO ET AL., AMERICAN JOURNAL PATHOLOGY, vol. 165, 2004, pages 901 - 912
TAKEUCHI ET AL., GASTROENTEROLOGY, 1999
See also references of EP 2471917A4
DATABASE GENBANK [online] 31 May 2009 (2009-05-31), KUNTZEN, T. ET AL.: "Definition: Hepatitis C virus subtype la isolate 03P, complete genome", XP008150561, Database accession no. EU781810
DATABASE GENBANK [online] 2 January 2008 (2008-01-02), DONLIN, M.J. ET AL.: "Definition: Hepatitis C virus isolate 6025 polyprotein gene, complete cds", XP008150566, Database accession no. EF407427
DATABASE GENBANK [online] 2 January 2008 (2008-01-02), DONLIN, M.J. ET AL.: "Definition: Hepatitis C virus isolate 8003 polyprotein gene, complete cds", XP008150560, Database accession no. EF407439
DONLIN M.J. ET AL.: "Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy.", JOURNAL OF VIROLOGY, vol. 81, no. 15, 2007, pages 8211 - 8224, XP008150565
HEPATORIGY, vol. 10, 1994, pages 1321 - 1324
BIOCHEM. BIOPHIS. RES. COMMUN., vol. 183, 1992, pages 334 - 342
SCIENCE, vol. 285, 1999, pages 110 - 113
SCIENCE, vol. 290, 2000, pages 1972 - 1974
J. VIROL., vol. 76, 2002, pages 2997 - 3006
J. VIROL., vol. 77, 2003, pages 3181 - 3190
TATENO ET AL., AMERICAN JOURNAL PATHOLOGY, vol. 165, 2004, pages 901 - 912
TAKEUCHI ET AL., GASTROENTEROLOGY, 1999
See also references of EP 2471917A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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